ID H2Z8I6_CIOSA Unreviewed; 759 AA.
AC H2Z8I6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000013898.1};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000013898.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000013898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2Z8I6; -.
DR STRING; 51511.ENSCSAVP00000013898; -.
DR Ensembl; ENSCSAVT00000014058.1; ENSCSAVP00000013898.1; ENSCSAVG00000008144.1.
DR eggNOG; KOG3544; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000163310; -.
DR HOGENOM; CLU_367200_0_0_1; -.
DR InParanoid; H2Z8I6; -.
DR OMA; FTYQSIC; -.
DR TreeFam; TF334137; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR CDD; cd00033; CCP; 6.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00084; Sushi; 6.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00032; CCP; 7.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 6.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50923; SUSHI; 6.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..759
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579104"
FT DOMAIN 121..182
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 183..243
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 244..304
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 305..366
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 367..426
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 427..485
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 562..739
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DISULFID 185..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 214..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 246..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 275..302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 337..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 397..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 759 AA; 82625 MW; 3613133444409E8B CRC64;
MKIFCLITLL FLSSQSVEGL RCFTCNGASS NEECNLKGRI VQCQPNEGSC QNEVRLSEGK
YYTITKRCKQ TEACSNNQEQ NDKPAWEPTQ CYPQFTMNSV CRCCCSKNEC NARAMPCDKA
PKCPAPVQPL NGQVTCSNMN FGNSTCTYEC EQGYTLVGSS EITCMENGFG LKWASETPRC
ERKTCGASVP RSPPNGKVTC SNSNRVGSSC TFTCDRGYEV VGSSRVVCNR DQSWSNNVPL
CNRVTCDSSL TIFLTNGEVS CAEFNFYSSQ CSYKCNQGFN LVGSSTSTCQ ADGSWTAGKP
ECQKITCDIA KTTSSIANGE ALCSDSNDYA SVCTYTCTRG FIRVGEESIT CQEDGTWSGN
AAECIPVNCD QTAPVVENGN VLCSNGNIFE SSCLFTCNEG YLMLNPGNMV CQDNSRWTKS
APSCQQIVCT PRQNDIDNGI VECSDNNVFG SLCTYLCNPG FEMQGLPTMS CGVNGWSNPP
PFCQQLTCPT TQTGPTSGRV ECTMENKAFS DCKYICGDGT DRWELHGSNS TSCQYDTVTQ
SFEWSADPPC CARQCPPYAQ VDLFLVLDSS SSVGKENWNK TVFFMKDIID NFVISPNDML
VAAVRYNKVI DTDSEIKIGR YTDLKSTTDA IVNLPYDGSG TLTGNALYYV LQNMLTAPGN
RPDVQDLVLV VTDGISKDDV ATPATMLRAT GTNVVALGIV NQKGSLKEED IIDIADDPEK
TVLLDTGFEG LSTELVEVIL KQVCGNPCER ENQYSGLAF
//
