ID H2Z9Y4_CIOSA Unreviewed; 944 AA.
AC H2Z9Y4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000014399.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000014399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR AlphaFoldDB; H2Z9Y4; -.
DR Ensembl; ENSCSAVT00000014564.1; ENSCSAVP00000014399.1; ENSCSAVG00000008430.1.
DR GeneTree; ENSGT00390000018381; -.
DR HOGENOM; CLU_009165_1_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 456..695
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 944 AA; 106671 MW; E804D3E34531AE20 CRC64;
YLFSQVEDIP EFSMSAFELQ HVKTGSDHLH LARDDKNNVF SVSLRTTPMN STGVAHVLEH
VALCGSHKFP VRDPFFKMLD RSMATFMNAM TGADYTVYPF STQNEKDFQN LLSVYLDAVF
YPRLQKLDFL QEGWRLEHEI NTDPDSPIVF KGVVFNEMKG VMADPSYLYG TSMQSKLLPD
HTYGVCSGGN PANIPQLTWE ELKDFHAGHY HPSNARFITY GDLPLENHLK FINEKVMINF
DKIDPGTEVP LQSRWNNSRS ATIQCAPDDM AANQEKQTTY SKSFILPEVS DIFESFTAAM
ICNLLIDGPA SPFYKTLIES GMGSDYSPMT GYHSHQKEAV FSIGLQGINQ DDASKLDQII
RDTFVETAKN GFSSERIDAM LHRLELQHKH QSSQFGLGLT FNLMPIWQHG TDPIQALKVD
SIVKQFRQHL KTDDQFLQKK CTEYFLTNTH HLNLTMTPDP EYKASLEKRE KAQLESMLDN
LSHEDKTKVY EQAYSSLSVV ALQKDANLIP GMPPYYVFRQ YNRYETPVIT CVQPTNGVTY
FNAVLPVNGL RGDLMPYLPL FCEVFTQMGT HTTDYVTFSQ REDLVTGGLS ASATSSCFYG
DSMTSETSVR LSSHCLDRNV SSMFDLWGEL FREVNMNDTT RLQTLIRQRA QELANSVSFS
GHLFAMKSAA RPLAPSAGYS EQFGGLTQVN FMKQIADSDD IDDIIMKLNE IALYVLRNNK
DAVSRFALHA TPHAMSEATT SLTKFVENIQ LSDVVGKKLN GTTLKVPFQS QTGYFFFKYL
FSINLLFSIP NRTFHDLPLP VNFTSMCIAT NTPYSHADNP ALRLLARLIT TKFLHKQIRE
KGGAYGGGAK HGDDGIFRFY SYRDPNNWKT IQAFKDGVKW ALNGDFDQEN IDEAKLAIFQ
SIDSPVSPCN RGLNIFNSGL YDVTIQQHRD RLLDVAKDEL VDVA
//
