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Database: UniProt
Entry: H2ZFQ1_CIOSA
LinkDB: H2ZFQ1_CIOSA
Original site: H2ZFQ1_CIOSA 
ID   H2ZFQ1_CIOSA            Unreviewed;      1853 AA.
AC   H2ZFQ1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 36.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016417, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016417}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016417}.
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DR   Ensembl; ENSCSAVT00000016598; ENSCSAVP00000016417; ENSCSAVG00000009660.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     94    120       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    135    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    166    189       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    370    398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    691    709       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    721    739       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    812    834       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    884    909       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1134       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1155   1171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1183   1202       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1247   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1366   1390       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1440   1462       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1482   1501       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1532       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1566   1591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1612   1633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1669   1693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      105    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      690    913       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      927   1110       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1114   1399       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1447   1702       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1707   1746       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      397    433       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1853 AA;  211794 MW;  5C9C36E4DA7616BD CRC64;
     SQEGEAEEYS KDAKANADLE QGKTLPEYLQ GDVPDGYKCR PLVDPDPYYD DKNTYIILDQ
     NYVIYRFSAT RSLYFIGALN IFRRIAARIL VHSYPFTHII IFSRIIIMLT ILVNCIFMTM
     DTTDKDWVND YVERVFLGIY SFEMIVKVIS RGFITSSFTY MRDPWNLLDI SVIFTAYLSE
     ILIAFHVGID KLTVLRAFRV IRALKTISAH AGLKAIVSAL IESVKALKDV MILTLFCLSV
     FALIGLQLFM GSLRQKCIKT YNNTLLEAWN TQNYSVVTEP FYRSYDIPPE MLQSQFIFNT
     TEGDMWLCGN GSGTGHCWEG YTCYRAGPNP NYNYTSFDNF LWAFLSLFRL MAQDYWENLY
     MLTLRANGQV YLIFFMLVIF LGSFYLVNLI LAVVAMAYEE QHQIVAAEEE RKKAQMQKKK
     EELENILMEA SHVTPGTPTV SSPSSPRSLS SRRSSIRKKH NRWLLGNSIK EKKEKEEAAR
     QAASRLAVEV RTRVDNPPSL TVNRLIESYF LPECYDSDFA DDESSDRLSV DDVSAKLAPS
     RHASTNGHTN TRSNSTNNGT VVDRNGVVSL LHRNTFTNNT SLPEVLVERP RHDSECTSCD
     GELIHMDTLK PTLQRSRLAS IDQLTEPELA IVKRRALSQA SIMSAGKIFK VRRRKCGACW
     YRFTDVFCIW NCCGCWIKFQ KIMRKICDDP FFDLFITICI VANTAFLALE QHPMDPALNN
     VLKSANIFFT SIFTAELIIK MVGLQPFYYF QETWNCFDSI IVAASLLEFP LQGLNGLSVL
     RSFRLMRVFK LAKSWPTLNM LIKIIGNSMG SLGNLVLILF ILLFIFAVVG MQLFREKYNA
     VEGELRWHMK DFGHSFLIVF RILCGEWIET MWGCMHYGKE ISALCIPMFM LVQVVGNLVV
     LNLFLALLLS SFSADSFSSD EEEAPNAIQL SKIRIQRWIV FGRSTIATWR LSLTNVLNNE
     VKTKSTAISG NIFQNDMVTV YIDPPEKENV SITDIRPALC SSTGAGGLVK VPIAAIESDL
     DNQDSENDSD NSSICTNKSY GSDISSCTSS SMSNTEYEQM QKNKEEEGLI ADEPSACWPD
     RCSTRLACCR PPVDQGIYRV WWNARKICFR IVEHSWFEFF IILMILLSSG ALAFEDVHFR
     DRKALRQVLK YADRIFTYVF IFEMLLKWVG YGFKKYFTNA WCWLDFFIVG VSIVGLVAEA
     LKIDNLSSIR SLRTLRAFRP LRAMSRFEGM KVVVNALIGA IPSIGNVLMV CLIFWMIFSI
     MGVNLFAGKF FKCLNITDNV KLPATNFTYA NITYPVINKT ICQYLTNNVS PEIRWKNGDV
     NFDNALAGYL ALLQVATFKG WTVIMYDAVD ITDDDKQPIF ENSVWFYLYF VGFIVFGSFF
     TLNLFIGVII DNFNQQKKKL GGQDIFMTEE QRKYYNAMKK LGSKKPQKPV PRPKNKLQAW
     VFDIVTHQMF EITIMLLIVA NMITMMIESH NMSKTFEAIL EYVNYVFVAI FTGEALIKMF
     ALRHHYFKNP WNLFDFNVVI LSIIGSTMSE LINKYFVQPT LFRIIRLARI GRILRLIKGA
     KGIRTLLFAL MMSLPALVNI GLLLILVMFI YSIFGMSQFA YVRRSGGVDD IFNFETFANS
     FLCLFMITTS AGWDGLLSPM LNSEYPYCDP DLNNGNPNDT GDCGSPTTAI GFFVTYLIFT
     FLIVVNMYIA IILENFGVAT EESTDPLGED DFEMFYEIWE RFDPKATQFI TYANLSDFVD
     SLDPPLRVPK PNLHSLNSMD LPMVIGDRLH CLDVLFALTK RVLGESDELE GLRSSMEEKF
     MASNPSKVSY EPITTTLKRK QEEISAVMIQ RWWRRIRLLR TVRIASMLLT ERA
//
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