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Database: UniProt
Entry: H2ZFQ3_CIOSA
LinkDB: H2ZFQ3_CIOSA
Original site: H2ZFQ3_CIOSA 
ID   H2ZFQ3_CIOSA            Unreviewed;      1870 AA.
AC   H2ZFQ3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 36.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016419, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016419}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016419}.
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DR   Ensembl; ENSCSAVT00000016600; ENSCSAVP00000016419; ENSCSAVG00000009660.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     93    119       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    153       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    165    188       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    367    395       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    713    731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    761       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    834    856       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    906    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1138   1156       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1177   1193       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1269   1289       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1348   1368       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1388   1412       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1462   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1504   1523       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1554       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1588   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1634   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1691   1715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      104    400       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      712    933       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1020   1132       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1136   1421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1469   1724       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1729   1768       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      396    437       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1870 AA;  214112 MW;  F10E7634C1274856 CRC64;
     QEGEAEEYSK DAKANADLEQ GKTLPEYLQG DVPDGYKCRP LVDPDPYYDD KNTYIILDQN
     YVIYRFSATR SLYFIGALNI FRRIAARILV HSYPFTHIII FSRIIIMLTI LVNCIFMTMD
     TTDKDWVNDY VERVFLGIYS FEMIVKVISR GFITSSFTYM RDPWNLLDIS VIFTAYLSEI
     LIAFHVGIDK LTVLRAFRVI RALKTISAHA GLKAIVSALI ESVKALKDVM ILTLFCLSVF
     ALIGLQLFMG SLRQKCIKTW PPRLVDFLYN QYNPNINVRL FCFCFESWVE DECNFCFVRD
     SMWLCGNGSG TGHCWEGYTC YRAGPNPNYN YTSFDNFLWA FLSLFRLMAQ DYWENLYMLT
     LRANGQVYLI FFMLVIFLGS FYLVNLILAV VAMAYEEQHQ VRLSEEERKK AQMQKKKEEL
     ENILMEVNKA ESRLQSRRAS HVTPGTPTVS SPSSPRSLSS RRSSIRKKHN RWLLGNSIKE
     KKEKEEAARQ AASRLAVEVR TRSSQKSNEG RRRFKKKLID VPPMNLLLGW ASSLTVNRLI
     ESYFLPECYD SDFADDESSD RLSVDDVSAK LAPSRHASTN GHTNTRSNST NNGTVVDRNG
     VVSLLHRNTF TNNTSLPEVL CTSCDGELIH MDTLKPTLQR SRLASIDQLT EPELAIVKRR
     ALSQASIMSA GMDDQRKCGA CWYRFTDVFC IWNCCGCWIK FQKIMRKICD DPFFDLFITI
     CIVANTAFLA LEQHPMDPAL NNVLKSANIF FTSIFTAELI IKMVGLQPFY YFQETWNCFD
     SIIVAASLLE FPLQGLNGLS VLRSFRLMRV FKLAKSWPTL NMLIKIIGNS MGSLGNLVLI
     LFILLFIFAV VGMQLFREKY NAGELRWHMK DFGHSFLIVF RILCGEWIET MWGCMHYGKE
     ISALCIPMFM LVQVVGNLVV LNLFLALLLS SFSADSFSSD EEEAPNAIQL SKIRIQRWIV
     FGRIKTKSTA ISGNIFQNDM VTVYIDPPEK ENVSITDIRP ALCSSTGAGV QSSDCRYDVA
     VDLQTDLNSS NMGLVKVPIA AIESDLDNQD SENDSDNSSI CTNKSYGSDI SSCTSSSMSN
     TEYEQMQKNK EEEVVEEACW PDRCSTRLAC CRPPVDQGIY RVWWNARKIC FRIVEHSWFE
     FFIILMILLS SGALAFEDVH FRDRKALRQV LKYADRIFTY VFIFEMLLKW VGYGFKKYFT
     NAWCWLDFFI VGVSIVGLVA EALKIDNLSS IRSLRTLRAF RPLRAMSRFE GMKVVVNALI
     GAIPSIGNVL MVCLIFWMIF SIMGVNLFAG KFFKCLNITD NVKLPATNFT YANITYPVIN
     KTICQYLTNN VSPEIRWKNG DVNFDNALAG YLALLQVATF KGWTVIMYDA VDITDDDKQP
     IFENSVWFYL YFVGFIVFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQRKYYNAM
     KKLGSKKPQK PVPRPKNKLQ AWVFDIVTHQ MFEITIMLLI VANMITMMIE SHNMSKTFEA
     ILEYVNYVFV AIFTGEALIK MFALRHHYFK NPWNLFDFNV VILSIIGSTM SELINKYFVQ
     PTLFRIIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALV NIGLLLILVM FIYSIFGMSQ
     FAYVRRSGGV DDIFNFETFA NSFLCLFMIT TSAGWDGLLS PMLNSEYPYC DPDLNNGNPN
     DTGDCGSPTT AIGFFVTYLI FTFLIVVNMY IAIILENFGV ATEESTDPLG EDDFEMFYEI
     WERFDPKATQ FITYANLSDF VDSLDPPLRV PKPNLHSLNS MDLPMVIGDR LHCLDVLFAL
     TKRVLGESDE LEGLRSSMEE KFMASNPSKV SYEPITTTLK RKQEEISAVM IQRWWRRIRL
     LRTVRIASML
//
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