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Database: UniProt
Entry: H2ZFQ4_CIOSA
LinkDB: H2ZFQ4_CIOSA
Original site: H2ZFQ4_CIOSA 
ID   H2ZFQ4_CIOSA            Unreviewed;      1900 AA.
AC   H2ZFQ4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-DEC-2017, entry version 36.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016420, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016420}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016420}.
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DR   Ensembl; ENSCSAVT00000016601; ENSCSAVP00000016420; ENSCSAVG00000009660.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     81    107       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    122    141       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    153    176       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    217    236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    267    287       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    371    397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    731    749       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    761    779       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    852    874       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    924    949       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1169   1187       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1236   1255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1300   1320       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1379   1399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1419   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1493   1515       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1554       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1566   1585       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1619   1644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1665   1686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1722   1746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       92    402       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      730    953       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      966   1163       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1167   1452       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1500   1755       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1760   1799       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      398    439       {ECO:0000256|SAM:Coils}.
FT   COILED      482    502       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1900 AA;  217838 MW;  DF9BCB24700B8681 CRC64;
     KANADLEQGK TLPEYLQGDV PDGYKCRPLV DPDPYYDDKN TYIILDQNYV IYRFSATRSL
     YFIGALNIFR RIAARILVHS YPFTHIIIFS RIIIMLTILV NCIFMTMDTT DKDWVNDYVE
     RVFLGIYSFE MIVKVISRGF ITSSFTYMRD PWNLLDISVI FTAYLSEILI AFHVGIDKLT
     VLRAFRVIRA LKTISAHAGL KAIVSALIES VKALKDVMIL TLFCLSVFAL IGLQLFMGSL
     RQKCIKTWPP RLVDFLYNQY NPNINTLYLN LYILLHILVF YTEWFSYIST NAVFESWVED
     ECNMWLCGNG SGTGHCWEGY TCYRAGPNPN YNYTSFDNFL WAFLSLFRLM AQDYWENLYM
     LTLRANGQVY LIFFMLVIFL GSFYLVNLIL AVVAMAYEEQ HQVRLSEEER KKAQMQKKKE
     ELENILMEVN KAESRLQSRR VRRNHVTPGT PTVSSPSSPR SLSSRRSSIR KKHNRWLLGN
     SIKEKKEKEE AARQAASRLA VEVRTRVDNP PSGSTPRASI RNLRLSPSVM KKDSLTVNRL
     IESYFLPECY DSDFADDESS DRLSVDDVSA KLAPSRHAST NGHTNSWEIG FQQTNAHHPL
     FILCPARSNS TNNGTVVDRN GVVSLLHRNT FTNNTSLPEV LVERPRHDSE CTSCDGELIH
     MDTLKPTLQR SRLASIDQLT EPELAIVKRM DDQRKCGACW YRFTDVFCIW NCCGCWIKFQ
     KIMRKICDDP FFDLFITICI VANTAFLALE QHPMDPALNN VLKSANIFFT SIFTAELIIK
     MVGLQPFYYF QETWNCFDSI IVAASLLEFP LQGLNGLSVL RSFRLMRVFK LAKSWPTLNM
     LIKIIGNSMG SLGNLVLILF ILLFIFAVVG MQLFREKYNA VEGELRWHMK DFGHSFLIVF
     RILCGEWIET MWGCMHYGKE ISALCIPMFM LVQVVGNLVV LNLFLALLLS SFSADSFSSD
     EEEAPNAIQL SKIRIQRWIV FGRRNLRQPS SVLNNEVKTK STAISGNIFQ NDMVTVYIDP
     PEKENVSITD IRPALCSSTG AGVQSSDCRY DVAVDLQTDL NSSNMGLVKV PIAAIESDLD
     NQDSENDSDN SSICTNKSYG SDISSCTSSS MSNTEYEQMQ KNKEEEPSAC WPDRCSTRLA
     CCRPPVDQGI YRVWWNARKI CFRIVEHSWF EFFIILMILL SSGALAFEDV HFRDRKALRQ
     VLKYADRIFT YVFIFEMLLK WVGYGFKKYF TNAWCWLDFF IVGVSIVGLV AEALKIDNLS
     SIRSLRTLRA FRPLRAMSRF EGMKVVVNAL IGAIPSIGNV LMVCLIFWMI FSIMGVNLFA
     GKFFKCLNIT DNVKLPATNF TYANITYPVI NKTICQYLTN NVSPEIRWKN GDVNFDNALA
     GYLALLQVAT FKGWTVIMYD AVDITDDDKQ PIFENSVWFY LYFVGFIVFG SFFTLNLFIG
     VIIDNFNQQK KKLGGQDIFM TEEQRKYYNA MKKLGSKKPQ KPVPRPKNKL QAWVFDIVTH
     QMFEITIMLL IVANMITMMI ESHNMSKTFE AILEYVNYVF VAIFTGEALI KMFALRHHYF
     KNPWNLFDFN VVILSIIGST MSELINKYFV QPTLFRIIRL ARIGRILRLI KGAKGIRTLL
     FALMMSLPAL VNIGLLLILV MFIYSIFGMS QFAYVRRSGG VDDIFNFETF ANSFLCLFMI
     TTSAGWDGLL SPMLNSEYPY CDPDLNNGNP NDTGDCGSPT TAIGFFVTYL IFTFLIVVNM
     YIAIILENFG VATEESTDPL GEDDFEMFYE IWERFDPKAT QFITYANLSD FVDSLDPPLR
     VPKPNLHSLN SMDLPMVIGD RLHCLDVLFA LTKRVLGESD ELEGLRSSME EKFMASNPSK
     VSYEPITTTL KRKQEEISAV MIQRWWRRIR LLRTVRIASM
//
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