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Database: UniProt
Entry: H2ZFQ9_CIOSA
LinkDB: H2ZFQ9_CIOSA
Original site: H2ZFQ9_CIOSA 
ID   H2ZFQ9_CIOSA            Unreviewed;      1857 AA.
AC   H2ZFQ9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016425, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016425}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016425}.
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DR   Ensembl; ENSCSAVT00000016606; ENSCSAVP00000016425; ENSCSAVG00000009660.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     81    107       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    122    141       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    153    176       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    217    236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    365    393       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    724    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    754    772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    845    867       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    942       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1151   1169       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1190   1206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1218   1237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1282   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1369       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1389   1413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1463   1485       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1505   1524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1536   1555       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1635   1656       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1692   1716       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       92    398       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      723    946       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1033   1145       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1149   1422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1470   1725       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1730   1769       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      394    435       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1857 AA;  212346 MW;  BB1F9ADB5AE4BC38 CRC64;
     KANADLEQGK TLPEYLQGDV PDGYKCRPLV DPDPYYDDKN TYIILDQNYV IYRFSATRSL
     YFIGALNIFR RIAARILVHS YPFTHIIIFS RIIIMLTILV NCIFMTMDTT DKDWVNDYVE
     RVFLGIYSFE MIVKVISRGF ITSSFTYMRD PWNLLDISVI FTAYLSEILI AFHVGIDKLT
     VLRAFRVIRA LKTISAHAGL KAIVSALIES VKALKDVMIL TLFCLSVFAL IGLQLFMGSL
     RQKCIKTWPP SRNVFSYKTR NVTNYLTTMT TVHCTTVLIT FKFTVLFLIT GNFCFVRDSM
     WLCGNGSGTG HCWEGYTCYR AGPNPNYNYT SFDNFLWAFL SLFRLMAQDY WENLYMLTLR
     ANGQVYLIFF MLVIFLGSFY LVNLILAVVA MAYEEQHQVR LSEEERKKAQ MQKKKEELEN
     ILMEVNKAES RLQSRRASHV TPGTPTVSSP SSPRSLSSRR SSIRKKHNRW LLGNSIKEKK
     EKEEAARQAA SRLASSGNQS TKSRSGKHKT TDLQIFELHF FCSPACNTKF ISFGLTKFFP
     DLISRAITEL QQQQMAEDNT VHHDQDSLIP PHHPHSILSS DRLSVDDVSA KLAPSRHAST
     NGHTNMVDRN GVVSLLHRNT FTNNTSLPEV LCTSCDGELI HMDTLKPTLQ RSRLASIDQL
     TEPELAIVKR RALSQASIMS AGMDDQRKCG ACWYRFTDVF CIWNCCGCWI KFQKIMRKIC
     DDPFFDLFIT ICIVANTAFL ALEQHPMDPA LNNVLKSANI FFTSIFTAEL IIKMVGLQPF
     YYFQETWNCF DSIIVAASLL EFPLQGLNGL SVLRSFRLMR VFKLAKSWPT LNMLIKIIGN
     SMGSLGNLVL ILFILLFIFA VVGMQLFREK YNAVEGELRW HMKDFGHSFL IVFRILCGEW
     IETMWGCMHY GKEISALCIP MFMLVQVVGN LVVLNLFLAL LLSSFSADSF SSDEEEAPNA
     IQLSKIRIQR WIVFGRIKTK STAISGNIFQ NDMVTVYIDP PEKENVSITD IRPALCSSTG
     AGVQSSDCRY DVAVDLQTDL NSSNMGLVKV PIAAIESDLD NQDSENDSDN SSICTNKSYG
     SDISSCTSSS MSNTEYEQMQ KNKEEEVVEE ACWPDRCSTR LACCRPPVDQ GIYRVWWNAR
     KICFRIVEHS WFEFFIILMI LLSSGALAFE DVHFRDRKAL RQVLKYADRI FTYVFIFEML
     LKWVGYGFKK YFTNAWCWLD FFIVGVSIVG LVAEALKIDN LSSIRSLRTL RAFRPLRAMS
     RFEGMKVVVN ALIGAIPSIG NVLMVCLIFW MIFSIMGVNL FAGKFFKCLN ITDNHLNMFT
     WQDNMSISHN NVSPEIRWKN GDVNFDNALA GYLALLQVAT FKGWTVIMYD AVDITDDDKQ
     PIFENSVWFY LYFVGFIVFG SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQRKYYNA
     MKKLGSKKPQ KPVPRPKNKL QAWVFDIVTH QMFEITIMLL IVANMITMMI ESHNMSKTFE
     AILEYVNYVF VAIFTGEALI KMFALRHHYF KNPWNLFDFN VVILSIIGST MSELINKYFV
     QPTLFRIIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL VNIGLLLILV MFIYSIFGMS
     QFAYVRRSGG VDDIFNFETF ANSFLCLFMI TTSAGWDGLL SPMLNSEYPY CDPDLNNGNP
     NDTGDCGSPT TAIGFFVTYL IFTFLIVVNM YIAIILENFG VATEESTDPL GEDDFEMFYE
     IWERFDPKAT QFITYANLSD FVDSLDPPLR VPKPNLHSLN SMDLPMVIGD RLHCLDVLFA
     LTKRVLGESD ELEGLRSSME EKFMASNPSK VSYEPITTTL KRKQEEISAV MIQRWWR
//
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