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Database: UniProt
Entry: H2ZFW2_CIOSA
LinkDB: H2ZFW2_CIOSA
Original site: H2ZFW2_CIOSA 
ID   H2ZFW2_CIOSA            Unreviewed;       843 AA.
AC   H2ZFW2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   15-MAR-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016478, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016478}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016478}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016478}.
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DR   Ensembl; ENSCSAVT00000016659; ENSCSAVP00000016478; ENSCSAVG00000009695.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    419    443       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    482       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    558    575       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    587    612       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    652    671       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    788       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     78       {ECO:0000256|SAM:Coils}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   843 AA;  97452 MW;  A663B03BDC373F5B CRC64;
     MGSLFRSEEM CLAQLYLQSE AAFACVSELG ELGLAQFRDL NPDVNAFQRK FVNEVRRCDD
     MERKLRFLEK EVKKDNLAID DTGENPPAPL PREMIDMENK FDKLETEMKS VNSNQEALKK
     NFLELTELKH ILRKTQQFFE QIILTKYKKN NNQAALYQQD QETHVPQQYD DETPLIASEF
     SRSFNRFGFV AGVLMRDKIS AFERVIWRAC RGNVFLRYTE IEAELEDPHT GDKVNKYVFI
     VFFQGDQLKS RIKKICTGFR ATLYPCPETP QERREIALGV MTRIEDLQTV LNQTADHRRM
     VLSQVALNIR VWLIKVRKIK AIYHTLNLFN VNIEKCLIAE CWCPVVDIDR IQLALRRGTE
     LSGSSVPSIM QQMQTKENPP TYNQTDKFTS GFQAIIDAFG VSNYREVNPA PFTIITFPFL
     FAVMFGDMGH GLLMFLFALY LVLKENRYMK HKPEDEIFKM MFDGRYLILL MGLFSIYTGF
     LYNECFSRSI NIFGTSWNVR AMNFTDNDVF LATNPVVTLD PNKPGVFRGY PYFYGIDPIW
     QSAENKITVQ NSYKMKNAVL MGFAQMIFGL SLAFCNRRHF KDKLTLYCEL LPQLLFLCAL
     IGYLCMCILY KWSVWTVAQS NTAPSLLIGL IDMYMLTDPK SNNRVPLYTG QYQVQIFLVI
     VTVLCVPWMF LSKPYILYKR SKQKKGVRLD SQSDDDVAIL HHENNDANYG KQEPESFDMS
     EVIIYQAIHT IEFCLSCISH TASYLRLWAL SLAHSELSEV LWSMVMHTGL ATSGTSGAIL
     SFFVFWFFSS LTVSILLVME GLSAFLHAIR LHWVEFQSKF YKGEGYIFSP FSFTLIVEGK
     VEE
//
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