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Database: UniProt
Entry: H2ZFW6_CIOSA
LinkDB: H2ZFW6_CIOSA
Original site: H2ZFW6_CIOSA 
ID   H2ZFW6_CIOSA            Unreviewed;       837 AA.
AC   H2ZFW6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   15-MAR-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016482, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000016482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000016482}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000016482}.
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DR   Ensembl; ENSCSAVT00000016663; ENSCSAVP00000016482; ENSCSAVG00000009695.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    559       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    571    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    789       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     78       {ECO:0000256|SAM:Coils}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   837 AA;  96838 MW;  6BC6D38F001184C5 CRC64;
     MGSLFRSEEM CLAQLYLQSE AAFACVSELG ELGLAQFRDL NPDVNAFQRK FVNEVRRCDD
     MERKLRFLEK EVKKDNLAID DTGENPPAPL PREMIDMENK FDKLETEMKS VNSNQEALKK
     NFLELTELKH ILRKTQQFFE QAALYQQDQE THVPQQYDDE TPLIASEFSR SFNRFGFVAG
     VLMRDKISAF ERVIWRACRG NVFLRYTEIE AELEDPHTGD KVNKYVFIVF FQGDQLKSRI
     KKICTGFRAT LYPCPETPQE RREIALGVMT RIEDLQTVLN QTADHRRMVL SQVALNIRVW
     LIKVRKIKAI YHTLNLFNKC LIAECWCPVV DIDRIQLALR RGTELSGSSV PSIMQQMQTK
     ENPPTYNQTD KFTSGFQAII DAFGVSNYRE VNPAPFTIIT FPFLFAVMFG DMGHGLLMFL
     FALYLVLKEN RYMKHKPEDE IFKMMFDGRY LILLMGLFSI YTGFLYNECF SRSINIFGTS
     WNVRAMNFTD NDVFLATNPV VTLDPNKPGV FRGYPYFYGI DPIWQSAENK ITVQNSYKMK
     NAVLMGFAQM IFGLSLAFCN RRHFKDKLTL YCELLPQLLF LCALIGYLCM CILYKWSVWT
     VAQSNTAPSL LIGLIDMYML TDPKSNNRVP LYTGQYQVQI FLVIVTVLCV PWMFLSKPYI
     LYKRSKQKKG VQHNRLWYTC LDSQSDDDVA ILHHENNDAN YGKQEPESLL IIMLISQFDM
     SEVIIYQAIH TIEFCLSCIS HTASYLRLWA LSLAHSELSE VLWSMVMHTG LATSGTSGAI
     LSFFVFWFFS SLTVSILLVM EGLSAFLHAI RLHWVEFQSK FYKGEGYIFS PFSFTLI
//
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