ID H2ZGL2_CIOSA Unreviewed; 3447 AA.
AC H2ZGL2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000016728.1};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016728.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000016728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR Ensembl; ENSCSAVT00000016910.1; ENSCSAVP00000016728.1; ENSCSAVG00000009836.1.
DR GeneTree; ENSGT00940000166124; -.
DR HOGENOM; CLU_000042_2_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 27.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 29.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR PANTHER; PTHR24026:SF125; FAT-LIKE CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG; 1.
DR Pfam; PF00028; Cadherin; 20.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 29.
DR SUPFAM; SSF49313; Cadherin-like; 30.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00232; CADHERIN_1; 11.
DR PROSITE; PS50268; CADHERIN_2; 30.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..106
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 107..214
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 236..328
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 329..431
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 432..536
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 692..788
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 789..894
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 895..1005
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1006..1116
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1112..1214
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1216..1321
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1349..1480
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1481..1602
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1611..1654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1655..1774
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1790..1894
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1875..1980
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1981..2082
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2092..2185
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2186..2292
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2293..2399
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2395..2498
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2518..2608
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2609..2714
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2715..2824
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2825..2929
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2930..3031
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3051..3124
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3125..3225
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3226..3330
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3342..3447
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 662..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3447 AA; 378991 MW; CB43B07EA7C1E9D2 CRC64;
FTQPSYSARV QERAATGKAR VESSTMMGMW WSPVTEGVRY SVLGGGSDFE VRPRLSGNFI
FIDLWSGTLN SDREIQIRAM SSDQRSETQC TIHVHVVDAN DFQPLFPPQP YSVSIGEDTP
IGSTITVVTA TDSDRDPDNT RFYYSLKGNT GNFAIHPTTG RVILTGEISR RAQKQHSMQI
TAIDRKAALS GTAYPKETKL TVDVKSVNAH APKILVTQIS MLQNPAAFTE SGPNKITCAT
LKISDPDSGR HGDIAYTRIV KGDPERLFEV EPGVKRNEKR IVFSRVPPPI NGVMNLTVEV
SDNGLPPRSS RVSIQIQLYD RDSFIPKFKK DVFKMRVSEA SPPHTQVGFV EVAGNPNSIR
FALLSGNSRK TFKVHEKTGL ITTRRRLNRS SKSRYSLTIA ATNISLVLGD ARNTTTVVID
VEDSNDHDPM FTETSYRVEM SESTPVGGLV IQIHAEDEDA GNNGSVFYTL LGNPDKFTID
PINGTITTTQ TLDYDLMRTS YKLRVRASDR GTPFSRKSEC FVFVTISNMN DNAPMFDESD
CEILMSKSLT PGSPLVQLNP VDIDHDPVTC SLLSGNKDLF EIEDLTCLLT LRSNPGRLRI
GTVYNLEIVA TDGQLTSDVV FTNITISSMD GTTNKCGKTG RVERYEESLN LRLLSSNSGK
NIAASSNVNR TSQIPNTHRP QVRPGAWSNI HIPEDTAVGT SVTKVQAFDR DHGFNGKLWF
TITDGNSDSC FSIDTENGAV SVVKPLDRER TSSYNLTVSI SDLGSPSKTS SARIFISVTD
INDNAPYFGQ THYAFRLREN VRVGFVIQQN IWATDHDVGR NANITYSLSS AMGGEKFSIN
KTTGFIKVIE GLDRESTSEY RLTVTATDGG KIPLSSSALV LIDVTDVNDN PPRFHQSIFR
IKVTEDLPVG TVVFRLQSSD PDSPENSVVR YSLTAGVSNR AHAGEPKFNV DPRTGYIRIS
AGLDYRLKTR YNITARARDS NYRVATCYIE VEVVPVNRNL NAPYFDLPEV KFDVLENAAI
GVTVGIATAV DEDITQPENS SGYSIVDGTG LGIFNIDENT GILTTNRQLD RETERFYWLT
VKATDRGAIP LSGTMFVLIE VGNVNDNAPL PSEPIYFASV NENTPTGSQV CRIEALDLDG
DRDTISYSLS TNNTFFKINS STGVISFTIK NASRPENTVI SVSVVISDGG TPPLTSLAKV
VVELTDENDN SPKFLPNIEY TLNIPARNRT RNPTEVARVV AHDRDTGRNS NIDYRIHGKG
RFEINPKTGE ITTEHAFKEN MISVVKIIAM DNGNPPRQSK IQRLEIRWTA QPISSILAPK
FVSSSIEDVL IFESVEKKYQ GSAEQSNYVA LIQATDEDST DLRYMIMGSL SADFSLEHFQ
ANHSGNEDLM FHLNNEIGSL LVTGFPDAET KRKYNLTLLV TDGYNSDIAN VSLTFSAFLS
QNSMILDLFF LLGIHWEMLL ILFAWIVIRI GDLNDHRPEF EEPVYEGTVL ENTPVGTRVM
QVTAVDGDID LDRNGNMIYR IWSSIHPSSQ DLFRITSDGV IYTQGNLDRE VQKEHIFIIE
VDDQGSPSLS VARGLSFDII SPRFYCRVVI TIGDVNEHPP RFTASRYSGH VTVGVADESV
GPDDMASTSI VTGTSASASI TVDVQDVNDN RPEFEQLGYT GSVSESSGSS PSSSVVGMTG
PLIVRASDGD SRDNGRIRYL IAGISDEINS RFSVDQYTGA IRTKAGMNLF DYELVQHYSF
EVQASDIGNP ALSSSQNAQV IINILQTDEA PPKFSKPHYN SILYTPTGNG AIVSQEVSAH
YTDSSVQHNI TYSITGGNIG SAFSINPKTG VVTVNSATLL QNEYALRLQA SDGKRKSVSA
LTVSLRSLES ELHFSRQRYE AEVMESSTEI APVVVVSVVG MVLEDNIRFN ILNPTPHFII
GVTSGIIETT GVAVDREATP SYEVQSIDVN IQQSGSKTPR RGRCIVHVTI NDCNDNDPQF
VGIPYYASVQ IDAPPQTAVK QIRAVDLDIG LNGEVRYSLS GRYSELFSVH PTSGNVTVKR
TPADVLGSNN QIVKIISLTG TPSRIGKSLL HLSLVNRATP VFTQSFYDAI MVPEDAKAHT
VITSSVQAAS PDSSDVYYTI EGGDSLQQFD IDFVGGTITT LGNLDFEQRT NYRLQVRARD
AASRAYSDVQ VLIQVVDIND NDPIFIQTSY TKSLPENTRV GTEVVKVHAV DLDSGSFGAI
SYSIIQSPTS DGGQFLIDFD TGVIWTASNL DAETQQIMEF VVRATDGGSP AKYSDVTVTL
SVEDVNDNPP EFEKVNYEFY ISAEASYQSF IGKVTAIDPD SSETNLVYSI RQSENAVMEI
NPQSGIISLN HNNIGNNVKR IYGNISATDG LYTTSADVVV HVSYDDTSPT PLIFHQPTFN
FSIEENQPTG TSVGFIRASG KGDLIYSADI DPSIPFHIRE NTGEIITLQS VDREALLLDA
HAEAIITMNC RVTDEIGQVS HAVVNVKVLD VNDNPPVFTM SSYSAVLVVP DVQLYDEVLQ
VTALDPDYGV NGTIDYSIDQ DLNIAKNFFK LDSDSGLLTI RQIPYQRGNV QVLNFFIRAT
DTGEVEQLNG LTAVSIYLTT HAESVPVFDR KIWEASIPED RLTSNVCLSL NSRHYPKYIY
IPILSNTTDL FPQDEFFYID PVTGKISMNN HIDGDRWPVF NLTVLAFVKT TPELVTSAKV
VVRITDVDDC VPKFVSEYYE ASVTEELPGG QDVIRVHAVD LDRGNHDMTY RFEFVVVFLE
WEKGSTASNL FTIDSQTGQI RTLKPLDHEK DQDFELNVLA ENGAEDRTTV YVKVIDINDS
PPQFTKPQYS INIPESISVG QVTARFLRIS DNDTTASADT HVYITSGDPH GKFKAIYNKG
NQNKNILKPL DREEQGHYDL TIIATDGLHS ATSVVSVEIG DINDNTPKCS QLWYEGRVSE
DAPTHTLLLR VVSTDADISE AGRISYQLSG TGSNQFNLDP RTGELLTSSP LDREATSAYW
LTAISMDGGD KQCSSKIHIT IEDVNDNAPI FESASLRHST RENTPVNSSL HRIVAFDPDQ
DDVNKQFSVE PRTGVLVLNK PLDRETVPSY QLEIVAIDDG AERMSSTATL HLQILDVNDN
PPIFDQNQYS AAIPEDSQVG LIVVPVAAHS LDTGANAKLR YSIVHGNEHG KFVINQDSGE
IRLIAHVDFE SDQSYVLTTE VPTPLSTDCA VRIDIIDVND NSPIFSSLSY QTDVSEDAEI
GRVIISAKAT DRDSGNAGNI TYSFAPNQIL PFAINSDTGE VRISDPGLDF ETQKTFSIQI
AATDKGAQPR SMSAILTVNI NDVNDNRPAF IDSSNCTVFV HESSSNSVVH GIIGLNASDA
DGKTNGKPFK YRIAVGNTAD LFYLDHHNVL KSRQPLRLSN DGTQNFVHLQ TFGGLVKFSF
DCGGGPQVII RETQKINDGH WHDISVQ
//
