ID H2ZHB2_CIOSA Unreviewed; 1287 AA.
AC H2ZHB2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=K Homology domain-containing protein {ECO:0000259|SMART:SM00322};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000016978.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000016978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 51511.ENSCSAVP00000016978; -.
DR Ensembl; ENSCSAVT00000017161.1; ENSCSAVP00000016978.1; ENSCSAVG00000009989.1.
DR eggNOG; KOG2208; Eukaryota.
DR GeneTree; ENSGT00940000168637; -.
DR InParanoid; H2ZHB2; -.
DR OMA; DHAGQQV; -.
DR TreeFam; TF323767; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22405; KH-I_Vigilin_rpt1; 1.
DR CDD; cd22413; KH-I_Vigilin_rpt10; 1.
DR CDD; cd22414; KH-I_Vigilin_rpt11; 1.
DR CDD; cd22416; KH-I_Vigilin_rpt13; 1.
DR CDD; cd22417; KH-I_Vigilin_rpt14; 1.
DR CDD; cd22418; KH-I_Vigilin_rpt15; 1.
DR CDD; cd22406; KH-I_Vigilin_rpt2; 1.
DR CDD; cd22407; KH-I_Vigilin_rpt3; 1.
DR CDD; cd22408; KH-I_Vigilin_rpt4; 1.
DR CDD; cd22409; KH-I_Vigilin_rpt5; 1.
DR CDD; cd02394; KH-I_Vigilin_rpt6; 1.
DR CDD; cd22410; KH-I_Vigilin_rpt7; 1.
DR CDD; cd22411; KH-I_Vigilin_rpt8; 1.
DR CDD; cd22412; KH-I_Vigilin_rpt9; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 14.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10627:SF69; PROTEIN BICAUDAL C; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 14.
DR SMART; SM00322; KH; 14.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 13.
DR PROSITE; PS50084; KH_TYPE_1; 14.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 137..205
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 209..277
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 282..350
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 351..417
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 422..490
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 516..585
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 612..680
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 684..754
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 759..828
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 843..912
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 916..1003
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 1004..1085
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 1097..1166
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 1170..1235
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1261..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 144280 MW; 8BC291D794B3B30E CRC64;
MNSVDSAQTS AAGDVVTNNV EPIPTYSEAF PPLAGDAAGN VASSSTENQW LNPKVQRLRS
TVVTQIFHIP MEERAFKQSE FGQAQKDQSK VCIDIMKQTD TVIEMSTCRD GSLSLLVSGK
AENVLKARRE IFNKLQTQAS ITINIPKDHH RVILGKAGTR LQKLELETAT KINIPRTEKQ
STELTIVGTQ EGIHRARQEI QMISDEQAKL AMERLPIEKI YHPFVSGPRN EFANQLIKEY
GVRIHIPPPS VQKDEIVVSG EKDGVAATVS KIMAVYQQKK RNCKIISVEI NKAQHKYIIG
PRGQTLQDIL AEASVSVELP PADSLSETVV LRGEPSKLGQ GLTIVYAKAN SVVIREVAAA
AWLHRFIIGK KGANIRALTA NLPRVNVEFH DEGNKIVIEG PPEEADQAQQ QLETQVHDLK
LRMDFAEVRI DPKFHKNIIG KGGQSINKLR DQYNVNIQIP TDTDKSSLIR IEGDPEGVKE
AKLELEQLGQ RLVYLGLNYF TKLFCLNRNS LLFQENEKSK DVLIEQRFHR NIIGQKGEKI
KGIRDSFPKV NISFPDAKKK SDVVNLRGPK NDGGECAIFI HCLLCLYIVE SIKNFCFVVI
LSAVLHILTV EKNYCIDVPI FKQYHKNIIG KGGANIRKIR EETNTQIDLP KEDSENEVIV
ITGKKADCQK ARKLIRAIEQ EQANIVEELV NINPQLHNQL IGAKGRLIRS LMEDYGGNVQ
IHFPTGTSGS DKVTIRGPKE DVEKAKGQLM QIAKQKELAS FTKELKCKAE LHRFLIGRGG
ATIKKVRDET GARIIFPASN DTDKETITVM GKQADVETAC RILEEKIKSM VIHFIPFSIP
FENIIEIETE IDQKHHKYFV ARRGAVLRDI ADEFGGVTVS FPRIGDQSST VRIKGPSECV
EGAKSKLAEI VDDLENQVTI ECLVDEQYHR TVIGQKGRNI QAVTAQFNVQ VKFPSRNNAP
SQSEQPEVVE NGVNGEVNKD LIMITGHKDR CQEAMAAILA LVPTSDQIEV PYKFHRYIIG
QKGLGVRKLM EDYDVTISIP PADQNSNFIT VCFIAQPSHA IPIQQITGVK SKLENAKAGL
MERVKVIEQE EEDRVLRSFT LTVDVPNQFH SQIIGRRGAI VTEIRTKHGV NIQFPDRDDE
NQGQIRIIGY EKNAESARDA VMKIVNELSS HISQDIKIDR KVHPRLIGTK GRAIKKIMED
FGVDIRFIKE EDIVTVTGPL EKVEECVEHI LNLEEEYVSS CSFSFIHLFF FKDTKRYSHS
NYADGQKSNK PSNKAPFVVR DAPWHQS
//
