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Database: UniProt
Entry: H2ZHJ7_CIOSA
LinkDB: H2ZHJ7_CIOSA
Original site: H2ZHJ7_CIOSA 
ID   H2ZHJ7_CIOSA            Unreviewed;      1723 AA.
AC   H2ZHJ7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000017063, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000017063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000017063}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000017063}.
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DR   Ensembl; ENSCSAVT00000017246; ENSCSAVP00000017063; ENSCSAVG00000010035.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     84    108       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    120    141       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    153    173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    211    230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    336    358       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    598    616       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    628    646       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    666    693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    714    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    827       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1077   1095       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1115   1132       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1144   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1201   1223       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1315   1339       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1402   1420       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1466   1494       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1515   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1613   1636       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       91    368       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      596    830       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1075   1348       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1397   1645       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      386    413       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1723 AA;  196369 MW;  89F4332E69878F0A CRC64;
     DELVDADLKP DPTLADGQEL PQYCGKFQKK YYNKPIEDID PYYKERGENT FCVVTRRFGS
     DYIYRFSAAR GCFVFSPFQP LRQLAIRIIL HPLFDAIVMT TILVNCVFLG LNEEIPAAEY
     LFTALYTVEM IVKIIGRGFV LNQFTYLRDP WNWLDFIVVI IAYVTLLGTA SNVSSLRTFR
     VIRAFKSVSI VPGLRTIVNA LFHSMKPLGE VMFIMGFLLI IVSLIALQAY QGVLRRRCVI
     YPPSGLSDQQ YFNFTHDSAN FNDVDGEQVV CGNSTGSGIC PVNYVCLPDV SDNPNYGHTN
     FDHMGYALLT SFQLLTLDYW ENVYNMIIRA EGPWNVLFFF MSVFLGPFYL LNLLLAVVTR
     AYSKEHDKQV SVKKQVLVKR RIYVKKSEFE ERRQQAKQRA KRKAIRRRKL LQKKASVNQA
     SLIGSDSVTT VGSFGDLVLA RMKPITEQPA LEEPVSAGEA SGGVNGSHSN LTQGSNGASK
     SKQAAFQNQR NELSMDSSDS CKCIFLVYFQ LVCINAFYGD TNKILYMFAQ HILVMLTEFA
     FPKNLTGFFS PAKKTRSIWY RRFKRIKNWY LTTFCSWNCF PGFIKFQKNL KKVIEHKLFE
     SVIMLSIIIN TVFLAIDHHG ISPELKHALE IGNHVFTGIF TVEAIIKITA LGPVEYSKTL
     WNVFDFIIVF ISLIEVGLTV SVGTSAAPDL TMLRTLRLLR VFRLARMWGT MNKLVSIIWK
     SISAVSYLTI VLFLVLYIFA VIGKQLYSAK YSASASRFDD NNVPRWSFID FYHSFLLVWR
     VMCGEWIEPL YDCMYITDND GLCIPLFLSI TFIANFMILN LFTAILLEAF TVDDLSKAKA
     NGEKKSEKWA SCIFFIYWSK EIANIIINIG GNCWNTLYEQ LGYFGNMIQR GMEKIRKKMK
     KKSQNVNPSP DTDDTCAKVE EVQNNSDKTV SIIYPSNFCF RIDCDHCEVN ELPKIHEEVQ
     EEVNSGIAGN GAHPNKFKAN EKGIQPNGIK HNLPSDNVKK TMGCFSLSCC SCMDARENEN
     IEVEEEDADE ETVSPPGCLP EWFLNRYPSC AETPDSTPFR LWSSIRMCCY ILVEHKFFEW
     FILFLILSST VCLAMEDVHL NSDPVRKLVL EKLEFVFTAL FTVEMILKWI GLGPVKYFTN
     LWCVLDCAIV AVSFIIKCCL ASWIGIVLSQ ASQFRSLRTL RALRPLRAIS RWQGMKVVVN
     ALLYCIPSIG NVLCVCLLIW FVFGIMGVQF FKGSFFKCVD ADENKVTDLR VVDLTTCLQF
     NYTWINPNIN FDHVGNAMIA LFQVATFEGW IEIMADASDV MGPEIQPRRE ASKYYLIYFV
     VFVLVGSFFI LNLIVGVIIE SFQNLRKQVG SLFEALLTDT QKNFYKTMRT MLNRKPKKTI
     SPPSNRWQLK IFNLVTHSKF ELAVFLLILM NMITLMMEHY KMSTEWASAL RGVDITFTAL
     FSLEAGLKLI GMRYHYFRDA FNVFDFIVIL VSIIGFILEN LVALIVSPTL LRVVRVFRVF
     RVLRVVRAAR GIRRLILTLM ISIPALFNIA VLLSVFIVIF AILGMTMFMN VKLNGALNDQ
     VNFQTFGNSL MVLFRLVTSA GWNDVMDPLM NTRDCEVSSH LAPGNCGDPV AAVIYFVAFI
     CIVFLVIVNM YIAIILENFD EIFKQDESGV SQGDFETFYM VWGRYDPRAT QFVTLTELSN
     LLHDLHPPFQ LPKPNLVKIG ALDLPVLYGD KVHCLDVLFA LVK
//
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