ID H2ZJD2_CIOSA Unreviewed; 2739 AA.
AC H2ZJD2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Fibrillin 2b {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000017698.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000017698.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCSAVT00000017890.1; ENSCSAVP00000017698.1; ENSCSAVG00000010416.1.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 19.
DR Gene3D; 2.10.25.10; Laminin; 45.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF12662; cEGF; 4.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 32.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 45.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 38.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 24.
DR PROSITE; PS50026; EGF_3; 33.
DR PROSITE; PS01187; EGF_CA; 17.
DR PROSITE; PS51364; TB; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 97..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 135..178
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 193..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 235..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 280..338
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 387..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 434..474
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 475..516
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 549..588
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..650
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 698..735
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 736..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 780..821
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 843..883
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 888..942
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 988..1029
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1030..1070
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1156..1197
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1198..1235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1240..1278
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1281..1321
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1322..1364
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1365..1405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1406..1446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1451..1507
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1524..1565
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1617..1672
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1680..1722
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1723..1760
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1765..1805
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1806..1844
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1845..1885
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1972..2027
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2041..2081
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2082..2122
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2166..2206
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2210..2250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2255..2311
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2323..2360
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2406..2442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2445..2483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2529..2567
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 101..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 119..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 553..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 702..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 740..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1810..1820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2739 AA; 295699 MW; 2C2E5073B1654BB3 CRC64;
LTGRNVCHEK GSTFCCPGWM TSVTGKSCTV AKCPEGSCGP RGLCTRPNEC MCSNGQTQER
CPREENERRC NMRCMNGGEC MDNQCRCPYG YTGPHCGQPI CGPGCLNGGR CIAPGRCACV
YGFTGMRCER DYRKGPCFHT RVNGTCKDEV PGVMCTKLFC CATVGEGWGH PCEECPARVG
NCTKGRLPPL CSDIDECEIM PGLCDGGTCR NTDGSFVCEC PKGYRADTQT HRCVDVNECA
SSDVCTYGNC INTDGGFICE CPPDYKLSSD STYCISDKPG RCYTAIESGM CARPLFELVR
RTMCCCTPTG EETLGKCFAA VGETAERCPA VGTRRFLCLS SSDNSLEQSI GIGCNSIRLD
SGLCELLGDQ ACSNGRCSPI ITLSHSDVDE CTQGGNYPSV CGPHGTCLNS DGSYTCHCSR
GFENDAGSMI SCIDIDECSQ DGLCEDGACV NTRGSYVCNC NDGFRPSATQ LECEDINECV
EQEGICENGR CVNAGGSFRC ICNPGFFTSP DSTSCLDENE CERDNMCANG ECVNMDGRYK
CANGQSCSDI NECRMNPCEN GRCENSEGSF QCHCHRFQRL DSTGTRCVLD QTMGDCFRGV
RNGQCRARNA LTGTSTRSDC CCALPGATSA WGESCEPCPE VRDADYTVLC HEVEISNICE
LLVNPCENGD CLRMGNNKYR CICNKGFVVA DDQLSCVDVD ECSKNLCSNG ACRNTPGSYS
CTCHDGFLLR GDVCEDIDEC VSNPCTQARC VNEPGSYRCV CSDGFSLDVT GHICYDVTVG
RCWRSYVNNE CSGNIGNRLL TKEECCNTLG QAWGNVNCRP CSDFTFPCDH GYKLNIQTNE
CENINECEIG VCEEGAECVD LDGSFRCECS PGLTLRSDGT SCTDVRVGIC YQDVSEDGYC
SGTSADTILM TKHQCCCTVG QGWGSPCETC PEKNTQAWRK LCIPDGLRDA FFFPNLCIGG
ECKNTDTSFT CLCNQGYTLD ESGNNCTDID ECVISPGLCG NGVCINTGGD FTCDCEEGYE
DSVTLKVCTD IDECSLPGHC TGGTCFNTEG SYECACPPGR SLGPDGTNCV GEIFYLLLIP
DLCEPNGRCE NMLGYYMCIC DVGYIPTPDA RDCVDIDECL DNNGGCHMGC TNTIGSYECS
CDDGFVLAFD GHTCADRDEC MEQMNRCDGG TCENTDGAFR CVCFDGFMAT ADLQFCEDID
ECAMNANVCM HGKCHNTRGS YTCNCEQGYC VPQGQMICVD EDECEMSKHN CHVNADCNNT
EGGYNCHCIP GFHGDGFMCH DDDECAMGTA LCHEVATCTN KHGSYECNCD EGYHGDGFLC
SDKDDCIEDD SLCGPHGQCL NVDGSFECDC PMGFVTTDDR KACKDIDECS IEGICVNGRC
HNVPGTFRCV CLDGYEKDDQ GANCTDVDEC TNLANCINGM CVNTDGTYEC QCPEGFQKNP
TGIGCVDTRT GNCFNSAEGD ELAPICTGQI GTDVTRGTCC CIDNAGAWGN PCELCPSVNS
SEYHTLCPGG PGFRTNPITV LLEDINECVE VPGVCRGGKC INGFGTYICE CSMGYQLNSA
TKTCEDINEC EGDTSDNEYD VCGAGLCLNT VGSYNCQCPE GYKSIMGGRK CEDIREKSCY
RYYNASSSDC SSPLDFVLTR KKCCCFSNIG QGWNNPCEPC PATGSDAFAS VCGSVDFIRT
NDMCGQINNL CENGVCISTE DGGYTCECSR GYEFNRDLIS CEDIDECEEE DLCFADSVCT
NMPGSYVCSC MEGFLFDEIS GTCVDIDECN LGSTCTNGAC TNTRGGFICD CNQGFVPINN
DKACEDVNEC DRDPCGRGVC QNVFGSFTCT CDTGFRISDN GDCVDKNECD EEGQCNNGIC
DNTPGGFACD CDEGYTVTPD GRVCIDTDEC TEDPIVCGIG TCQNMDGSFK CYCPDGYTSE
SGAACVDVNE CEAGDKCING ACVNTPGGFE CDCPKNSIVS ANKKTCIDQR EAHCYEQESQ
GVCSLPGNHA VKISTCCCQC TGGGWGSAED DCEACPSNGT LEFKNICPNG CGFTPDGIGE
YLNECEKNNP CINGRCVNQP GSFRCECTNG FTLDDTNRRC VDVNECVSSE DACGNGTCTN
TDGAFECDCD SGYYNGPEMT CLDVDECKPG LDLNQCVFRC VNTDGSFHCD CPNGFELRED
GRMCKDTDEC ASDDLNDCAE NGMTCKNMIG FFVCLCPSGY RSTTPGVCVD QNECDLAGVC
RNGNCVNLEG TFRCDCNEGY LYDEEHKMCL DTRTGFCYAQ IHQRMCEVTS TTGLPFTRAE
CCCNRGKGWA EAGEDCEECP HPGTALFVKL CPHGVGFKPN GDDIDDCHVT PGLCAHGTCI
NTLGAFRCAC SHGYESARSN KACIDINECL ATPNPCSFDC RNTEGSYECI CPKGYQIDAD
NSACVDLDEC AAKRHNCQYL CINTVGAFKC ECPHGFMQEG AQCVDKNECI DMPGICGPRG
ICRNDPGGYH CECPRGYRRD DMGQACMDVD ECNGQQSSCA GSCHNVPGSF RCMCSRGFRP
TMYGRGCSDV DECVHSPCSR GQSCSNKVGS FQCGCPAGLV KTQRGCGDVD ECQMGGGSCN
FGCRNSYGGF SCSCNNGFFR MGRGHCVSGG FQQRIPQRYP QFPQFGGFGM PPAPGMPPPP
PNTVCYACMP GGDTRRRHKR SPEEGKFIEV SGRHGRGMVN TSYPIELYLN SAKLTRRTPL
LQLQPSLKQL RNNVRYRIVG GNDDRKFRIH TRGGSSILH
//
