ID H2ZKA9_CIOSA Unreviewed; 4460 AA.
AC H2ZKA9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000018025.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000018025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 51511.ENSCSAVP00000018025; -.
DR Ensembl; ENSCSAVT00000018222.1; ENSCSAVP00000018025.1; ENSCSAVG00000010617.1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154076; -.
DR InParanoid; H2ZKA9; -.
DR OMA; QRENMAG; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 1841..1977
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2119..2317
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2447..2592
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1545..1572
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3034..3078
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3264..3312
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4460 AA; 509714 MW; 4DBED1420AB736B5 CRC64;
FTTYFTLRWD FLQSKTLKTL NLKVDKWAKM IMQEESKILV QEFLDKTDYF CLLIYLTPAG
QLNPSYEFPT SIKQKGTYFV KKEKLGVTKE NVRTKLIVGD ISQIPLDHMS PLVDEFLSHL
LSNDGNHQRW PAVVSDDVLR HVHKLKSNVY VVAGHVKGKT LLPLPVGSEK VDNAKAEERR
ALLHAIETVV IDWSHQVRDV LKQESAQPLL EGKNPGPSVE IDFWNAKCTN LECIYNQLKT
PKVKKMAAIL ELSHSSYYPA LRDIFTDVVS ALREARDIQM YLKPLRSFLD DFEQVDFTEA
IPKLAPLMHI VCLIWSQSKC YNTPVRIIVL LREMCNFLIE VTCNFLSPED ILKGEVDESV
EKVAAALKVL HAFRASFDDY KGKIDTFYED KSKVKYWKFA PELVFSRMDN FINRLDIVME
FFVRSQEFMK LEKIEFGGVK GRVLSQLVLN IFDGFQDLYK VFGERTYNPL DPEDPAFEDD
FDSFTQSLSD LERQLANIIC QGFDDCSGMA SICKMLNIFG SLLDRPIIKA DFDHKYPILL
RLFNTSLDKI KQIFDEHSCD DMPNTLKPCV HKNQPPVAGQ LKWVQELHER ITWPMELLQH
INHPVLCAFF RIFHSEECDL VFAKQEQMVK LIKEYENKIF EQWTSGVEEA CKFNLGQPLL
KRNPDTQLIS VNFDPQLVAV LREVRYMKYL NRLDIPDVAL ELYENHEMFR KYCANLDLTV
AWYNEVRNSV VDVEYPLVEG QLHEIDDVLR QAETQLCWKS EGIWEYIQAT RDRVNDLQVR
VQKTKMNIEK IEKIMKTWSE TPLFERKQSN PAAILNLEDR KDRLAKRYAM IIADGEAIHQ
CVKENLNFFN AVESSEIWQA YISYLDDMVI DGFFNCIFCS LNYFMENTDP DVQPLFIAEL
ELQSPDMVFR PSLMEGAPDG FLDLIEGLLV DIYKMSTLVP RIAPQVGQPD YKADMDDMAE
LAAMRGDLVS RVHEVIDKAI AYSQGFLEYG ALWTDDRQEF MKQFLTYGHI LAPEEVEMHG
DEGVPETPPT LTQFKEQIDS YEGLYQVISN VTATQVFDSW FLVQIKPFKQ ALLNTVKRWS
YMFKEHLINH VESSLSDLKE FIKVADLGLS KPIEEGDYDG LVECMGHLMA VRDRADATDV
MFEPLKQTIE LLKAYDQEMS EDVHLQLQEL PEQWNNTRKL SVTVKQTVAP LQANEVSIIR
RKCTSFDVKQ HEFREKFRKE LVFRFDCVAA YPNLDRMQEN VLDLKTEMIS LHESAGLFEV
NVPDYKQLKA CRREVGLCKG VWDLVQLVRT STDDWKTTLW ADINVEQMDI DCKRFAKDIR
TLDKEARAWD VFGGLDSLVK NMITSLRAVG DLQNPAIRDR HWHELMQAAK VRFTMDETTT
LADLLKLNLH NFEDEVREIV DKAVKEMGME KTLRELDVTW AAMDFEYEHH QRTQSPLIKS
NEELVETLED NQVQLQNLMT SKYIAHFLEE GSLGWQKLST ADSVLTIWLE VQRTWSHLES
IFIGSEDIRA QLPEDSKRFD GVDRDFKEIM ADAVTTPNVI EATNKKGLYE RLEDLQAKLT
LCEKALAEYL ETKRLAFPRF YFVSSSDLLD ILSNGNNPVE VSRHLAKLFD NMSKLKFEEE
EGGEASKSAL GMYSTEDEYV AFGELCHCTG QVELWLNRVM DAMRATVRNE LAEAVVTYEE
KPRDQWLFDY PAQVALTSTQ IWWSTEVGIS FARLEEGYEH ALKDYFKKQV QQLNTLIGLL
IGSLTPNDRQ KIMTICTIDV HARDVVAKLI QQKIESASEF VWQSQLRHRW DDEKKHCFAN
ICDAQFVYSY EYLGNTPRLV ITPLTDRCYI TLTQSLHLIM GGAPAGPAGT GKTETTKDLA
RSLGIMVYVF NCSEQMDYKS IGNIYKGLAQ TGAWGCFDEF NRISVEVLSV VAVQVKSIQD
AIRFKKKRFI FQGEEISLIP TVGIFITMNP GYAGRTELPE NLKALFRPCA MVVPDFELIC
EIMLVAEGFL EARILARKFI TLYTLCKELL SKQDHYDWGL RAIKSVLVVA GSLKRSDKTR
PEEQVLMRAL RDFNIPKIVT DDMPVFMGLI GDLFPALDVP RKRDLDLEKM CRQAVHDLKL
QAEDNFVLKL VQLDELLFVR HSVFVIGNAG TGKTQVLKSL MKCYQNMKRR PIWVDLNPKA
VTNDELFGII NPATREWKDG LFSTVMRDLS NVTHNGPKWI VLDGDIDPMW IESLNTVMDD
NKVLTLASNE RIPLTPSMRL LFEISNLRTA TPATVSRAGI LYLNPADLGW NPVVTSWIDK
REIQSEKANL TILFDKYIPA CLETLRGRFK TITPIPECAK IQMLCFLLEV LLTPENTPAD
CPKELYELYF VFACIWAFGG AMFQDQLIDY RLVEFSKWWT TEFKTVKFPS AGTVFDYCID
SETKKFLPWS ESVPAFELDP ELPLQACMVP TAETRRIRYF MDLLMEIRRP VMLVGNAGAG
KTVLVQDKLA ALPDDFMVTN VPFNFYTTSM MLQGVLEKPL EKKAGRNFGP PGSKRLVYFI
DDMNMPEVDA YGTVQPHTLI RQHMDYSHWY DRTKLILKDI NNVQYVACMN PTAGSFTINP
RLQRHFSVFA VSFPGQDALQ VIYSSILTQH LQMGGFPVAV QKMSNTLVQA ALALHAKINS
TFLPTAIKFH YIFNLRDLSN IFQGILFSTS DCVKNISDLV RLWMHEASRV YCDKLIDQKD
IEMFEKNKLE FAKKYFDDIP DEVLTAEPLL FCHFSAGIGD PKYLAVSTWQ AMNKLLVDGL
EAYNEVNAVM NLVLFEDAMS HIARINRILE SPRGNALLVG VGGSGKQSLS RLAAFISGLE
VFQITLRKGY GIPDLKVDLG ALCIKAGLKN IGTMFLLTDA QVPDEKFLVL VNDLLASGEI
PELLPEDEVE NVISGVRNEV KGAGLEDTRE NCWKFFIDRV RRQLKVVLCF SPVGSTLRVR
GRKFPAVVNC TQIDWFHEWP EEALQSVSLT FLQDIEGIDP EIKPSISQFM SYVHTSVNQT
SKMYLANDRR YNYTTPKSFL EQIKLYESLL GVKGKELQAK MERLENGLTK LQSTAAQVDD
LKAKLASQEV ELQQKNEDAD KLIHVVGIET EKVSKEKAIA DNEENKVAVF AVEVGEKQKS
CETDLAKAEP ALAAAQEALN TLNKNNLTEL KSFGSPPGAV VNVTAAVMVL LAPNGKVPKD
RSWKASKVMM AKVDAFLEQL INYDKENIHE NSLKAIRPYL DDPEFDYDFI KQKSGAAAGL
CAWCINIVRF YEVYCDVEPK RIALSKANSD LAAAQDKLSG IKAKIAQLDA NLAELTAKFE
KATSDKLKCQ QEAESTTLTI NLANRLVGGL ASENVRWAEA VSGFKEQEKM LCGDILLITA
FVSYVGYFTR SYRIEFMDQC WLPYMKKQEV PIPTTEGLDP LSMLTDDADI AEWNNEGLPS
DRMSTENATI LTNCQRWPLI VDPQLQGIQW IKRRYSNLKI VRLGQRGYLD VIEMGVSNGD
TVFIENVEES VDPVLEPLLG RNTIKKGRYI KIGDKEVEYH PSFRLILHTK LANPHYQPEM
QAQCTLINFT VTKDGLEEQL LAEVVRCERP DLEELKAKLT LQQNDFKITL KRLEDSLLSR
LSAASGNFLG DTALVENLET TKKTAAEIEI KVAEAKVTET KINEAREGYR VVALRASLLY
FILNDLNIIN PIYQFSLKAF NVVFSKAIER SEQSDDLKVR VSNLVQTTTY SVFQYTTRGL
FECDKLTFTA QVALQILLAN KEINLVEMDF LLRFPVKMDS TSPVDFLSNY SWGGIKVLSE
FEDFRNLDRD IEGSAKRWKK FAESECPEKE KFPQEWKNKS SLQKLCMMRA LRPDRMTYAV
QNFVEEKLGT QYVENRSVEF AKSYEESGPE TPIFFVLSPG VNPLKDVEAI GVKLGFTMDK
KNFHNVSLGQ GQEIVAEQAL DLAAQEGHWV VLQNVHLVAK WLSTLEKKIE KYSIGSHKSY
RVYVSAEPAA TRDSHIIPQG ILESSIKITN EPPTGMQANL HKALDNFNQE TLEMCSRETE
FKSLLQSLCY FHAVLSERKK FGPQGWNRPY PFNVGDLTIS VNVLFNYLEA NSKVPWNDLR
YLFCEIMYGG HITDDWDRKL CKTYLEVYMH PDQLEGELLL APGYPVPPNM DYKGYHEYID
EVLPPESPYL YGLHPNAEIG VLTTTSENLF RTLLEMQPKD AAGAGGGGAT REEKVKALLD
EILEKLPEEF NIVELLSKVE DRTPYIVVAF QECERMNILT KELRQSLKQL DLGLKGELTI
TSDMEELESA MFFDSVPESW TKRAYPSMFG LTAWFADLLI RIKELESWTA DFQLPNVVWL
GGLFNPQSFL TAIMQSMARK NEWPLDKMCL QCDATKKNKE DFNSPPREGS YIHGLFMEGA
RWDVQSGLMA ESRLKELTPA MPVMFIKAIP VDRQETKNIY ECPVYKNKSR GPTYVWTFNL
KTKEKSSKWI LAGVALLLQV
//
