ID H2ZKR2_CIOSA Unreviewed; 1717 AA.
AC H2ZKR2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000018178.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000018178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
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DR Ensembl; ENSCSAVT00000018376.1; ENSCSAVP00000018178.1; ENSCSAVG00000010696.1.
DR GeneTree; ENSGT00950000183166; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.30; -; 1.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR012331; Clathrin_H-chain_linker.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 6.
DR Pfam; PF13838; Clathrin_H_link; 2.
DR Pfam; PF01394; Clathrin_propel; 4.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 3.
DR SMART; SM00299; CLH; 6.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 6.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|PIRNR:PIRNR002290, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1373..1391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1717 AA; 197647 MW; D530E81FFF6E282C CRC64;
LQNVGINAAN IGFSTLTMES DKFICVREKV GDQAQVVIID LADSANPIRR PISAESAIMN
PASKVIALKG NFIYAKVIFI AGRTLQIFNM EMKSKLKAHT MNEDVVFWKW ISTNMIGLVT
ETSVYHWSME GFKILEILDS TITENQTNLN KEIFSLSIYI FTGDSQQPVK MFDKHPSLAN
CQIINYRTDA KQKWLLLIGI SAQSNRVVGA MQLYSVERRV SQPIEGHAAS FAQLKLEGNK
ESTLFCFAVR GAQGGKLHII EVGTPAAGNQ PFSKKAVDVF FPPEAANDFP VAMQVSPNQN
VVFVVTKYGY IHMYDLETAV CIFMNRISAD TIFVTAPHEA TGGLIGVNRK GQLFSRKFNT
LFAQGNYTEA AKVAANAPKV SGLGNIYDYL LKQEKCRESL FLESIFEVDL IRKFRLFQNC
FYILVFLIKG SAATRICSGI LRTSQTIQKF LSVPAQPGQS SPPLLQYFGI LLDQGKLNKF
ESLELCRPVL QQGRKQLMEK WLKEEKLECS EELGDLVKPM DSTLALSIYL RANIPNKVIM
CFAETGQFQK IVLYAKKVGY TPDYVFLLRN VMRVNPETGK QFAMMLVQDD EPLADVAQVR
SDFFNLYFIL GLRKFYAGYF NNSNYELNKL NCQCYQLNNL KYQCFQCSCT CNVNFKIVDV
FMEQNLIQQC TAFLLDALKN NRPAEGALQT RLLEMNLMHA PQVADAILGN QMFTHYDRAH
VAQLCEKAGL LQRALEHFVD LYDIKRAIIH THLLNPEWLV NYFGSLSVED SLEAMLTANI
RQNLQISVQV ATKYHEQLTT EKLIEVFESF KSFEGLFYFL GSIVNFSQDA DVHFKYIQAA
CKTGQIKEVE RICRESNCYD ADKVKNFLKE AKLTDQLPLI IVCDRFDFVH DLVLYLYRNN
IPKYIEIYVQ KVGSRFCTIW VILKRLSPMF LYLCDYFKVN SGRRKKLITF LCHFSNSLKK
IVLVKNDFFS VNKNIFSAFK IPHLPSTTGI RKDFPFKICA EYLCNENSLF KSEARYLVRR
KDVELWGKVL EDTNQYRRQL IDQVVQTALG EAQDPDEISV AVKAFMAADL PNELIELLEK
IVLDNSMFSD HRNLQNLLIL TAIKADSSRV MDYITQLDNY DAPDIANISI ENELFEEAFA
IFNKFDVNTS AISVLIDQIG KYHKNPIHYY NPRLGFDRPN RRFIIQTAFR VLIGHVKNLD
RAYEFAERCN EPTVWSQLAR AQLNAGMIKE AIDSYIKADD PSSYMEVVEA SNKSENWEDL
VRYLLMARKK ARESYVETEL VFAFAKTNRL ADLEEFISGP NNANIQQVGD RCYDQKMYEA
AKVLFNNISN FARLASTVVH LGEYQTAVDS ARKANSTRTW KEVNMINIKL KSFFIFFISL
FQIIILCLFY SKKVLIILDR GYFEELITML EAALGLERAH MGMFTELAIL YSKYKPGKMR
EHLELFWSRV NIPKVLRAAE QAHLWAELVF LYDKYEEYDN AVVTMMAHPT DAWKEGQYKD
IITKVANIEL YYKSLQHYLD YKPMLINDLL NVLSPRMDHT RAVAFFRKAQ RLALVKPYLR
TVQTHNNKAI NEALNDLLIE EEDYSGLRNS IDAYDNFDTI ALAQRLEKHE LIEFRRIAAY
LYKGNNRWKQ SVELCKKDLL YKDAMTYAGE SRDTELAEEL LEWFLDRQRY ECFSAGLYSC
YDLLRPDVVL EQAWRHGITD YAMPYLIQVM REYSTRV
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