GenomeNet

Database: UniProt
Entry: H2ZPU2_CIOSA
LinkDB: H2ZPU2_CIOSA
Original site: H2ZPU2_CIOSA 
ID   H2ZPU2_CIOSA            Unreviewed;      1807 AA.
AC   H2ZPU2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   10-MAY-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000019608, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000019608}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000019608}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000019608}.
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DR   Ensembl; ENSCSAVT00000019820; ENSCSAVP00000019608; ENSCSAVG00000011491.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     42     61       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     73     94       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    106    129       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    164    183       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    273    294       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    306    331       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    653    672       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    693    713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    778    800       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    858    879       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1093   1111       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1126   1146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1158   1177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1224   1244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1339   1362       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1424   1441       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1453   1471       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1478   1498       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1540   1568       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1641   1664       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       41    336       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      656    883       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1091   1370       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1424   1674       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1807 AA;  207179 MW;  F854EA2A4D8CC824 CRC64;
     QTYIVVNEHG SIFRFSKAES LFLLGQNSRL RTAAINLFIK PMFSNFIMLV IMFNCACMVL
     ENPPHWIDDY LEYVFTAIYI AEATVKIIAR GFVLHNFSYL RDPWNWLDFI VIIIKAILQS
     TMLGQIAVLR TFRVLRALKT MSVVPGLRGI VKALLRSIHA LKDAVALTVF CVSVFALIGY
     QLFHGTLRQK CVLNSGTFDL APNALYAIDR RQDIFNWDMD INNFTSTLQD YNTSTNTEPI
     YCAIGHDDMC PLGYTCNEAG DNPDFGYTSF DHFFLAFLTS FRLVALDSWS RLYYLTLHTI
     GKTYAIFYIL VVLLGSYYLV NLILAVVYMA YEEQQAVVEE EELNESCSEA HSSEIDVETG
     RWKLGLITTS LACHEPRSMS NDGNSSPTLS PSPFGYRESC RRKRRKRRRY RRKSPINLET
     QECPKTHNGG AALPNIRLIV TEIDSDRERD RRSSGFLNNS SSLLPGSSAN SNFLSVNSAF
     SRGRSSPTRN RDHRLSATSM QLQLPTAEKK SKERSAPPPV TQNKHRNRSF SVGAGLSVFT
     TSNSKKPNFT DAEEDSEYFQ ANNNLLSPVN PSPEKFTGVS ISQEKEEDHT IAVISEDGKY
     YEVDHVNNFL KVVSFMIIDK YRKLSRAFVN TFCKWRCCPA SWSKIQRKVR KIVLNPFTDL
     LITLCIALNT LFMSLEHHPM ETWFSKLLDQ ANVFFTIVFT VEMLMKIIGL SPYTYFKERW
     NVFDAVVVLF SLLELLISST QGLSVFRAFR LMRILKLAKQ WPTLNKLLRI IGRTLGQLWH
     LTLVLFLVLF IFAVVGMQLL RDSYLTYYNE HNQGKQPRWN FVDFSHSFMV VFRIQCGEWV
     ENMFNCINVA SPGVCIPLFI LVYIIGNLVI LNLFLALLLN SFSGDVLQQT TSKNSSISEA
     FRRFAVWARR QRIKIQNIPF NQTDCSVITN TETTFMNAAN KKDNNIIANE LKVPTLNGNA
     NHEDQPNLSH ANNHCCDELK VKPTSRSEHE PPKEQRLKVK HRSRQLSTCS SLQSDSTMSK
     LRTSRTTSLD SRPESRRAHQ KSRVSETNSV PVSPEHTVGR SRLASIKARE REPTSGPWFE
     IRRFVNKIII HKYFENFVIF CILISTVTLA MEDIHIDKRP AMKRVVQIVD IFCCIFFTIE
     MLMKWIGKGL KSYFTNPWCC LDFFIVIVSI INLSLVANQR SDFSALRALR TFRALRPLRA
     LSRFQGMKIV VDALVRAVPS ITQVFVICMI FWLIFSILGV NIFGGRFGRC VSFSDATFVV
     YLNLNKISFL ITSCLNFSRM NTTLINWQIP NVNFDSAPRG LLALLQIATF TGWLEIMGSA
     VDITGIESQP RYEASFYNYL YFCVFIIFGA FFSLNLFIGV IIDNFNQQKI KTTGGEDGVF
     LTDEQRRYYN AMKRMASKTP KKPIPRPNSR FANKIYDIVT DRKFEIAVMG LIMLNLVVMA
     IEHHDMSPKM YRLLQNFNLG FICIFLLEAI LKLIGLRLYY FTVPWNVFDI LVVVVSLIGE
     FSLDVMTQYF VQPTIFRIIR LFRVTRILRL IREAKGIRTL LFALMMSLPA LFNIGSLLFL
     LMFIYAIIGM SQFPYIQKVA GVDSLLNFET FPNAFLVLFQ ISTSEGWDTF IEPVLRDREP
     YCVEKPEDGS PSNCGNSTIG VIYFVTYVMI TFLIVVNMYI AIILENFEVA TRESAEPLTA
     DDFEQFFEVW QRFDDRLTQY VSYDQLKSLL NQLDYPLRVA HPNGAFISQA HMKVTLDGNI
     HCLEVIITLI KKVLGDSPEL SNLKDSMLQS FQLKCPTKES LEDQETIDSE EFTVRLRAVL
     IIQQAYR
//
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