ID H2ZU52_LATCH Unreviewed; 1880 AA.
AC H2ZU52;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN Name=CCDC88A {ECO:0000313|Ensembl:ENSLACP00000000923.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000923.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000000923.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01121781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01121790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014347237.1; XM_014491751.1.
DR STRING; 7897.ENSLACP00000000923; -.
DR Ensembl; ENSLACT00000000932.1; ENSLACP00000000923.1; ENSLACG00000000825.1.
DR GeneID; 102359511; -.
DR CTD; 55704; -.
DR eggNOG; KOG4643; Eukaryota.
DR GeneTree; ENSGT00940000155559; -.
DR HOGENOM; CLU_001421_1_0_1; -.
DR InParanoid; H2ZU52; -.
DR OMA; AVATHIQ; -.
DR OrthoDB; 3091995at2759; -.
DR TreeFam; TF320231; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000000825; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR CDD; cd22229; HkD_Girdin; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947:SF30; GIRDIN; 1.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 13..133
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 219..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1129..1387
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 228..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1843..1880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1880 AA; 216704 MW; B5DCB45475567398 CRC64;
MESEKLFTPL LEQFMSSPLV TWVKTLGPSA RGNGRKLDEY VDLVDGIFLN EVMLQINPKS
ANQRINKKIN NDAFLRIQNL SILVRQIKLY YQETLQQLIM MSLPNVLVLG RNPLSEQGIE
EMKKMLLLLL GCAVQCEKKE EFIERIQSLD FDTKAAIAAH IQEVTHNQEN VFDMQLVETA
DLSQEDFDSL FRSMTFHLKR LVDERDEYSE TIIELSQERD CSHYPPHVPT AQSPSGSPSM
RRTESRQHLS VELADAKAKI RRLRQEMEEK SEQLMDSKQE VEQMEAELKK LQQENMQLLA
DARSARAYRD ELDALRDKAI RVDKLESEVI RYKERLHDVD FYKARVEELK EDNQVLLETK
TMLEDQLEGS RSRSDKLHEL EKENLQLKAK IHDMEMDRDL DRKKIEELIE ENMALEMAQK
QSMDESLHLG WELEQLSKTT ELCEVPQKSL GHEVNEFTSS RLLKLEMENQ SLSKTVKELQ
STMDSVEESN SRVLRMEKEN QRLSKKLERL ESEMNHEQQS LQNTETLSND LMKEKAQLEK
TLETLQENSE RQIKILEQEN NHLNQTIAAL RQRTQIGTEG RVKDIEKENK ILHDTIKETS
SKLNKMEFET KQMRKQLEHY KEKGERAEEL EKELHCLERE NDQLQKKITS LKISCEKVEA
LEQENSNLEL ENRKLKKSLD SLKNLTFQLE TLEKENIQLD EENLELKKTV KSLKSSTIKM
AQLELENKEL ENEKGQLKKS LELMKASSKK TERLEVSFQG LDTENQRLQK TLDNSNKKIQ
KLENELQDLE TENHTLQKNL EELKISSKRL EQLEIENRVL EQENSQLEKD KKQLEKENKR
LRQQAEIKDS TLDENNIKLS NLEKENKLLN KEIGIIKESC IRLKELEKEN KELVKRGTID
KKTLVTLRED LVSEKLKTQQ MNNELEKLTH ELEKMGLNKE RLLHDEHSTD DSRYKLLESK
LESTLKKSLE IKEEKIAALE ARLEESSNFN QQLRQELKIV KKNYEALKQR QEEERLTQSP
PPRPGDETQT AHKWEKESQE ATRELLKFKD RLIEVERNNA TLQAEKQALK TQLKQLETQN
NNLQAQILAL QKQTVSLQEQ NTTLQTQNAK LQVENSTLNS QSASLMAQNS QLHMQQSTLE
NENESLIKER EELKSMYDLL IKDHEKLAAL HERQAAEYES LINKHGSLKC AHKNLEVEHK
DLEDRYNQLL KQKAQLEQLE IVLKAEQEKM HLEALKHETV ATEYEKLRNE NDRLNFTHSE
LLKENEGLQT DHKNLKSLLN NAKLDQTRLE AEFSKLKEQY QQLDITSTKL NNQCELLSQL
KGNLEEENRH LLDQIQTLML QNRTLLEQTM ESKDLFHVEQ RQYIDKLNEL RRQKEKLEEK
IMDQYKFYEP SPPRRRGNWI TLKMKKLIKP KRDSNRDRLK SLTLTPTRSE SSEVFLQLPL
QDSQDSSSVG SNSLEDSHFG TKKSSMAALK KLPFMRNRPK DKDKMKSLYR RSMSMNDLMQ
SMVLAGGQWS GSSENLDGPD DPAAGQRRKE LGAMAFSTTA INFATANSSS GLRSKQILKP
KDASSFEDVG PHSINEDSSI GSSQASRPTS LDSSRTSSSN SNNNASLHDA KGPHNSSQSR
PQSHSSGEFS LPHDHEAWSI SSSPVHHSKR SSKPSPLLHR KIPGMLDVQC KQKHKASSPG
SEVVSLQQFL EESNKLSPTQ VCSTSQENLL DEVMKICSDS FEQVGREKQY PVSDGMFASS
NGKTTVDFAD GRPPKPGQFV KPSPRTIEST CAPIRPTLGN QGKAISVAEK INAIQPSVQS
TDCSAYATLP RASSVISTAE GSTRRTSIHD FMSKDSRQPV SVDPLPTKAS TSSQAALNVE
NIQESTKTKS RSWEQQSSQT
//
