ID H2ZVR4_LATCH Unreviewed; 1061 AA.
AC H2ZVR4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000001485.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001485.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000001485.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; AFYH01258136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01258142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZVR4; -.
DR Ensembl; ENSLACT00000001498.1; ENSLACP00000001485.1; ENSLACG00000001329.1.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000164755; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR InParanoid; H2ZVR4; -.
DR OMA; SHASMIR; -.
DR TreeFam; TF316816; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF41; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..48
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 155..188
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 305..377
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 479..557
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 810..906
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 969..1051
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 75..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 114833 MW; 2E5F51BB352640D4 CRC64;
LSGTTRQPKD GEIPGVDYNY ISVENFLALQ QSGGLLESGM FKGNYYGTPR PAAVPEAGNA
ITYQEHKPAT RNLCQRNRSV SNLERVGSAE AQENDEERTG VDSAATRGSS FTELYLLIER
STVAPPQNSP KVSDETWNTS VSVDSGDPGA YEELGPLPEN WELAYTENGE IYFLDHNNKT
TTWLDPRISA REASSSVEAN SDQYSPLFLI KLINTLPFPY QTDQFCVLFI KLQSILSPSP
YQSPTLVNSD KDDVSSPQPK CPIPEFLPRV PAAFSPMGQT EITAKKHGMY GFTQDPSELR
GHSLRTRLTK GAAGFGINVM GGTKPKEFLQ IASVVPHSPA ALNANVEAGD IVVFIGGTCV
LGFSHRQAVR MFQSVPKGGS IDMVLCRGYP LLDSEHQTST SMCKGTSIRL HSKDPVSDSD
VQSPATDSSM EAGVCSGDDF SARKLSPDYK RTNGFEAGIR DSGLYLSPVT LATTLQLVPV
PLAKSHQGLG FSVVGCRSGG GARVQRIWDG RSCPLLEGGD VIIKVNGADT RTLSAEQIEE
ILQQFTKEGD VILLVQRGGN LPKILKLSKR DPNADIQAPV SPDVSRHPLK VPAAPQNSLP
EPFAAASFKP SKSATKVVTF QDSHGAPTPS SSRSQGDPDR RPGLKSAMHQ DRDERQSQPG
CFSERNGQVR RLSDHAMRTG ASVRFSNPAP FAGVGPNSNE DLPGFQESPG TSRTKIPPHG
KERVKGTSFI GSTPSALGEQ AQKRSWRSDE AHLAGEKPGP DSVSRNRRAP GDGAVQAGLH
EPPGLSSGAG NIGGGFRVGE SSAREPELME VVLERREDEG FGFVMVTSIS RPTWGNTATA
RAGLTVPHRI SEIRKGSPAD RCGQLRVGDR LEGVEGRSIV NMPHREIADL FRRAGTRIHL
RVIPWRRKST YRFTVLPLVV SISVSNNTHR YPVSVNNKTN IIIPPGTFNS FDLTDQNQAS
KQTDSGYYSV VLDRGPVGFG ISLRGGREYK MGLYILGLMD QGPAQRDGRI QPSDQVIEIN
GKETAGMSHA MAVEEIRRGG SRLHLLLKRG SGYVPDYGES N
//
