ID H2ZWA6_LATCH Unreviewed; 1115 AA.
AC H2ZWA6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=PIGO {ECO:0000313|Ensembl:ENSLACP00000001677.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001677.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000001677.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; AFYH01170037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006006311.1; XM_006006249.2.
DR RefSeq; XP_006006312.1; XM_006006250.2.
DR AlphaFoldDB; H2ZWA6; -.
DR STRING; 7897.ENSLACP00000001677; -.
DR Ensembl; ENSLACT00000001690.1; ENSLACP00000001677.1; ENSLACG00000001501.1.
DR GeneID; 102357909; -.
DR KEGG; lcm:102357909; -.
DR CTD; 84720; -.
DR eggNOG; KOG2126; Eukaryota.
DR GeneTree; ENSGT00910000144278; -.
DR InParanoid; H2ZWA6; -.
DR OMA; YPSFDIF; -.
DR OrthoDB; 5479199at2759; -.
DR TreeFam; TF354249; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000001501; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1115 AA; 123353 MW; E5049450DECAB8C1 CRC64;
MNKLPALIAL LWICLLFYVG IGLFMSGFLL VRVELGNRSS CADQLFAGGK SAAGTEEEPL
GQSCWAARRF RRVAVVVIDA LSYEFAKFDP ENRSPRPYQN RLGVIHRLVS ARPRNARLYP
FRADAPTTTM QRVKGLTTGS LPTFIDISSN FASYAIQEDN LIQQWVQNGR KVVFMGDDTW
DGLFPNQFSK SYFFPSFNVK DLHTVDNGVL RHLYPSVKDG NWDVLIAHFL GVDHCGHRYG
PDQPAMADKL DQMNDMLGSL IDQLQNDTLL MVLGDHGMTD DGGHGGDSEK EVNAALFVYS
ALPLFREEAD QAPESIPQID LVPTLALLTG IPIPYSNIGK VIPDLFRWSN ERDALSPDFT
LVEALWINVK QVNRFLDSYS LAATDLPQDQ LQRLKELFAS AGSEYAALHA RRSQPLPNLT
RRLQKLVSDL QLYLKEARET CQASWARFQP LRMLIGILIL AATCLLCYVV SETADRPGLY
HGVSLSPIAW GAAVGLAFGT WQVVSGSGLE PWAAPCLAAL ASQLGFCVHL WRLRSQESGQ
SLSERPSPLR PSPLQSSKPW AGFSVPLVIL FLRCASVFSN SFVVAEGQAV LFLLKSLLVS
TVAGLHWAGK LSAPNPVTHP NFGPETPKQS IWQAYKRESV HLLGFLAAFL VCVNFSVVFH
GCREEQAACQ PSPFLTPLSG LQDQQARNWN YALCLAPLAG LVLLPRLWLR HYGNLNNGGP
AILFVRWGVP LAALLLSFYW AMNSAPESSY GKLLVLVRSA VVVFPHLMYG LVALGLLVAW
WSPMTVFLKV TGRSAEDEEA ELVTASRGTL GAEGNLLHVI PQIYRKMQRN LRNRLGAGEG
AAGGEEEQRP VAAAYGLGSV YSAAVLIVVW LLALLLLLLH TERMSLSFLL LFLEAFAFLQ
LHAAFINLSA QDSGDFTVPW YAVTGWAFAA TQFFYSTGHQ PTFPTIQWNA AFVGFPEGHD
NRIVVPAALL GMNTFASHII FAVSSPLLMF WPLVCETQGL RKRRGGKDSW GGDEEQTMEM
RLRESPQRFT AGLLQLGARY LFAHGVQLLA SVCTAAILRR HLMVWKIFAP KFLFEAAGFV
VTSVCSVLGI AFVMRVDVAV SRWFKQLILD QRHSR
//
