ID H2ZWQ5_LATCH Unreviewed; 1184 AA.
AC H2ZWQ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 4 {ECO:0000313|Ensembl:ENSLACP00000001826.1};
GN Name=HCN4 {ECO:0000313|Ensembl:ENSLACP00000001826.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001826.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000001826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR EMBL; AFYH01241581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01241590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006012369.1; XM_006012307.1.
DR AlphaFoldDB; H2ZWQ5; -.
DR STRING; 7897.ENSLACP00000001826; -.
DR Ensembl; ENSLACT00000001839.1; ENSLACP00000001826.1; ENSLACG00000001630.1.
DR GeneID; 102345376; -.
DR KEGG; lcm:102345376; -.
DR CTD; 10021; -.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000154743; -.
DR HOGENOM; CLU_005746_15_0_1; -.
DR InParanoid; H2ZWQ5; -.
DR OMA; YTPIPGQ; -.
DR OrthoDB; 74296at2759; -.
DR TreeFam; TF318250; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 222..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 554..669
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 130019 MW; 3A47A19421C4D551 CRC64;
MDKLPPSMRK RLYSLPQQIG AKASIMDEEE GDKDTRKKSI RMKALPSPAS GGTKGMGEGR
GGGESPIVET DVGKLGKTSS NGDCRRFKGS LSSIASRHLH DSESAEEKCL ITEGEATPSE
EKNPTGEMSS ETEQGAPKGQ QQGSSDQQAA FIRVEGADQI LPEDDQRFQA SFMQRQFGAM
LQPGVNKFSL RMFGSQKAVE REQERVKSAG FWIIHPYSDF RFYWDLTMLL LMVGNLIIIP
VGITFFKDEN TTPWIVFNVV SDTFFLIDLV LNFRTGIVVE DNTEIILDPQ RIKMKYLKGW
FVVDFISSIP VDYIFLIVET RIDSEVYKTA RALRIVRFTK ILSLLRLLRL SRLIRYIHQW
EEIFHMTYDL ASAVVRIVNL IGMMLLLCHW DGCLQFLVPM LQDFPEDCWV SLNRMVKDSW
GKQYSYALFK AMSHMLCIGY GQQAPVGMSD VWLTMLSMIV GATCYAMFIG HATALIQSLD
SSRRQYQEKY KQVEQYMSFH KLPADMRQRI HDYYEHRYQG KMFDEDSILG ELSEPLREEI
INFNCRKLVA SMPLFANADP NFVTSMLTKL RFEVFQPSDY IIREGTIGKK MYFIQHGVVS
VLTKGNKETK LSDGSYFGEI CLLTRGRRTA SVRADTYCRL YSLSVDNFNE VLEEYPMMRR
AFETVALDRL DRIGKKNSIL LHKVQHDLNS GVFNYQEKEI IQQIVQHDRE MAHCAHNIQN
PMATVSTPTP VIWTPLIQAP LQAAAATTSV AIALTHHPRL PAAIFRPPPS VLSSLGQQSS
QTPRQLKRLQ SLVPTTGTSA AGSPCSTTSQ LQTPGAETPS PASFQSHQPM SSLASVILSQ
VQQGAISPVP AGLSQHGSSG GASLGLNQFQ HASTGSPSLS MTQLQQLSSS PLTAGLNQFQ
PTSASSPSAS FNQLSSSSPS GLLNQLQPSS RSPQLQQFTN SGPSSGQTPF QPPASNSPSS
SLSQLTQVVG GSPSTSSQGQ PSIPGPISGT IAQLQQERSA FSSQLLATAS PCYTPPSAPS
PTVQSPVAGR NFPYGPSGAL GSQGSLLIPQ TCNIPPQVLQ PQSALPIPTG RLTQDIKLIS
ASQPSLPQEI SHPMSRSSPH SSRESIPGFT PPFSTGPALL SRPCSSVPGR MTLSRQMSSG
SLPHPLMFGA MAASLPSAAT VSRKGSVMFT TELEPVRSKL PSNL
//
