ID H2ZXI6_LATCH Unreviewed; 350 AA.
AC H2ZXI6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=inositol-phosphate phosphatase {ECO:0000256|ARBA:ARBA00013106};
DE EC=3.1.3.25 {ECO:0000256|ARBA:ARBA00013106};
DE AltName: Full=Inositol-1(or 4)-monophosphatase 3 {ECO:0000256|ARBA:ARBA00042949};
DE AltName: Full=Myo-inositol monophosphatase A3 {ECO:0000256|ARBA:ARBA00042119};
GN Name=BPNT2 {ECO:0000313|Ensembl:ENSLACP00000002107.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002107.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002107.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate;
CC Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005152}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000256|ARBA:ARBA00009759}.
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DR EMBL; AFYH01247417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01247418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01247419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01247420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01247421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01247422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006012858.1; XM_006012796.2.
DR AlphaFoldDB; H2ZXI6; -.
DR STRING; 7897.ENSLACP00000002107; -.
DR Ensembl; ENSLACT00000002123.2; ENSLACP00000002107.2; ENSLACG00000001885.2.
DR GeneID; 102346788; -.
DR KEGG; lcm:102346788; -.
DR CTD; 54928; -.
DR eggNOG; KOG3853; Eukaryota.
DR GeneTree; ENSGT00940000160216; -.
DR HOGENOM; CLU_034742_0_0_1; -.
DR InParanoid; H2ZXI6; -.
DR OMA; DELHKQP; -.
DR OrthoDB; 3665671at2759; -.
DR TreeFam; TF314300; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR CDD; cd01640; IPPase; 1.
DR Gene3D; 3.40.190.80; -; 1.
DR Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR PANTHER; PTHR43028; 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1; 1.
DR PANTHER; PTHR43028:SF4; INOSITOL MONOPHOSPHATASE 3; 1.
DR Pfam; PF00459; Inositol_P; 1.
DR SUPFAM; SSF56655; Carbohydrate phosphatase; 1.
DR PROSITE; PS00630; IMP_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
SQ SEQUENCE 350 AA; 37825 MW; B6C833E52350EE90 CRC64;
MAPMGIRLSP LGIAVFCLLA LGVLYHLYSG ILAGKLAVWR LGDVGQPGPA ATRRSEVDLR
ELLALSVEAA VRGGQEVRRI REGNSLDEKS KGETKEGAKE MLTTGDLLSH RKMFNLIKNT
FPNIKVNSEE HDDAGIQDTA SWDGVIPQEI ESKISVTRVV PTESITVWID PLDATQEYTE
DLRQYVTTMV CVAVDGKPVI GVIHKPFSSY TAWGIVDGGS NVKARTSYSE KSPRIIVSRS
HAGKVKSVAQ QAFGNNTVII QAGGAGYKVL SLLDTPDVKQ EQADVYIHVT FIKKWDICAG
NALLSALGGH MTTLKGEEID YSGSPGNEGG LLASIMMNHD ALVEKLPNIE
//
