ID H2ZXL7_LATCH Unreviewed; 357 AA.
AC H2ZXL7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279, ECO:0000256|PIRNR:PIRNR000543};
GN Name=NDUFA10 {ECO:0000313|Ensembl:ENSLACP00000002138.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002138.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR000543};
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC component of the hydrophobic protein fraction.
CC {ECO:0000256|ARBA:ARBA00011514}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC {ECO:0000256|ARBA:ARBA00008606, ECO:0000256|PIRNR:PIRNR000543}.
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DR EMBL; AFYH01069805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005995992.1; XM_005995930.2.
DR AlphaFoldDB; H2ZXL7; -.
DR Ensembl; ENSLACT00000002154.1; ENSLACP00000002138.1; ENSLACG00000001912.1.
DR GeneID; 102357619; -.
DR KEGG; lcm:102357619; -.
DR CTD; 4705; -.
DR GeneTree; ENSGT00390000016151; -.
DR HOGENOM; CLU_050591_0_0_1; -.
DR OrthoDB; 6357at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000001912; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR CDD; cd02030; NDUO42; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR015828; NDUFA10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW ECO:0000256|PIRNR:PIRNR000543};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000543};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR000543};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR000543}.
FT DOMAIN 62..273
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 357 AA; 41347 MW; 13F57F12CFBFA837 CRC64;
MAAALGFGAR GLWKVVSARA LWAAGQKARL HVSATRKLQY GWLAYVLGER TTSRFNEKSK
IITVDGNLAS GKENVARNLA DKLGMLYMPE ADVHYLDRIT GDGQLLDPRF SGNCSLEKFY
LDPKCPDGNS YRLQFWMYTV RLLQYSDALE HLICTGQGVV LERSPYSDFV FLEAMYKQGF
IRKECVEHYN EVKGISICEF LPPHIVIYVD QPVSEVEKRL KSRRQRFKYN LPIDYLKSIE
DAYKKTFLPQ ISETSEVLEY NIEQVQNIER VVEDIEYLKF DKGPWLEQDD VTFHRLRLLV
QDKDKVSDLV IIPRFLPEVT IGAHEYDKAY HDYKSLPGRK YDAGFNADVG DKWIWLK
//
