ID H2ZXN2_LATCH Unreviewed; 2273 AA.
AC H2ZXN2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRZ1 {ECO:0000313|Ensembl:ENSLACP00000002153.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002153.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR EMBL; AFYH01231332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000002153; -.
DR Ensembl; ENSLACT00000002170.1; ENSLACP00000002153.1; ENSLACG00000001923.1.
DR eggNOG; KOG0789; Eukaryota.
DR GeneTree; ENSGT00940000155529; -.
DR HOGENOM; CLU_001120_1_0_1; -.
DR InParanoid; H2ZXN2; -.
DR OMA; DPINCES; -.
DR TreeFam; TF351978; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd17669; R-PTP-Z-2; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF461; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1595..1619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..276
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 290..387
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1675..1950
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1867..1941
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1981..2240
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2157..2231
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1498..1522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1523..1542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2273 AA; 251864 MW; 591E32976DE11564 CRC64;
FHRQHSKNKE QKFWISTGPL DQKNWGRKYP TCNGAKQSPI NIDDDLTQVN VNFRKLKFEG
WEEESSENTF IHNNGKTVEI NLTNEYYVSG GGLISRFKAS RITFHWGKCN ASSDGSEHSL
DGRKFPLEMQ IYCYDVDHVN TFDEAMKGHG KIKALSILFE IGVNDNSDYD AIISGVNSVS
RFGKRAQLEP FVLFSLLPNS TEKYYTYNGS FTTPPCTEMV EWIVFKDTVT LSKSQLEVFC
EILTMQKSGY VMVMDYVQNN FREQQYQFVG QVLSSYTGSE EIHEPVCSSE PENVQADPKN
YTDMIVIWER PRVVYDAVIE NYAVFYQQLV GEDQSKHEIL TDGDQDTGAI LNNLLPNTSY
VIQVVAVCAN GLYGRRSDQL IVDMPLDDPA EIDPFSDLNE TEDISNEMQV MFKKEEETAL
DPEISASSET GLTEKLNVEV TKNISSASKD MKEKMGRKTG YEEDYNGQED SKNKLNFVLH
SSTLPRTEPS SVKPLVVLYP KTKTVTTPNP VESISVSFKN KHFDTSMEHQ QINASVISKS
IIETAVTSYE NVSSPTLPSE HAYVGSSGAN TTAFTNLTTE RSPLLEKTYS ENGTQQDLHM
PVSSSSNDPT DTGISYNNVS ASFDIEISNK TISSAFDAQL VLHNHTSSSD AKKSLESNHT
RTSSKISVPS TSSYSNGEMV PEGASSVDRE ILHNFTSGLS HEGALTHSAT SSSLQPFQHD
SASADRSTVL SQTTQPVFNG EISPQSSYNS DTLLLVTPLL SDNQMLLKAT PIASDVELVL
HATSVFPTVD VLPQPTPSSS SDAYLLKSSS ASFNSEVSLH IYTTFESQAL LKATPAVTSG
KVSLHAALVL SDGDALVQPT LTLSPDVASH QTTSPASETF MFGHRLDIFE ESETLPQVSP
FSNDFRVHAT QELPKGDTFI KPSLTLSSEV IFLQSFPASS DSASFVSDSG GIFLQVTPFV
SHTDLLMNEA SALSKASAVL QRTTSLPSDK FFGDIPISCG SELLFSRPGS FKEGQLVPMV
TSSISLDKLT CISSELVDVD MLNQPTCTLC GDNSLLQVSS VSASEMVSYD TIAPNKSRVM
PEHIFSVQHK YTAFESYNDL LIQTTLDVLL KTIFATSELH LSATQELAQG ISATLTDDVF
LAPTLQSSDE DTLFKPNLTF TVSTKTASVV KDSKLFLDSA NEYEKSLFED KTILHAASVL
PTIDCIASLQ DLTASLHIET PFPTIFSSSA NLLKATVDDY NNVLHQTTPF ESMMQPHSTS
VFSYPILQKY ATPAFTNDET LMSTAASIDN IVYNDIVPPS TSSNSLSNGI LFYVPSDFSQ
KALSVNPTLP LLNSNMYISV TAVPPISESP VTIALSPAPL EHSSVTSSNS SHDGLWPSVL
EGSLLIKNDT ASVLHAETML LEDSSAKTYN ITKNLTSHYL SVKSRPSGAF EEERFTTNAS
FYHRNTDMDK TNDPVSTSVS VIMSSQNTNM TVLEKQNQTV INPVKFTKDP TSWAFVASDE
ESGSGQSTSD NLNDNETSTD FSLPDYSERE SHGTGTAEDL HITKFKPRSA TPIKSHTVGH
KNVSSSIISV TEASNSSHES RIGAAEGLET ERKTLIPLVI VSALTFICLV VLIAILIYWR
KCFQTAHFYL EDNTSPRVIS TLAAPIISVS GVDVESISLK LFPKHVTNLH TKKGFTEEFE
TLKEFYEEIQ SCTVDLGITS DNSNHPDNKN KNRYINIVAY DHSRVKLAHL TEKDGKRTDY
INANYVDGYN KQRSYIAAQG PLKSTAEDFW RMVWEHNVEI IVMITNLVEK GRRKCDQYWP
SENSEEYGSF LVTLKTAKVL AYYTVRHFTV RNTKLKKGSQ KGRRNERIVT QYHYTQWPDM
GVPEYVLPLL TFVRKSSAAR SSEMNPVIVH CSAGVGRTGT YIVVDSMLKQ IRLEGTVNVL
GFLKHIRTQR NYLVQTEEQY VFIHDALVEA ILSKETEVLA SHIHAYVNAL LTPGPSGKTS
LEKQFKLLSQ SNVKQCDYSA ALKQCNREKN RSSSVIPVER SRVRLSSVAG EGVDYINASY
IKGYHHSSEF IITQHPLLHT TKDFWRMIWD HNAQVIVMLS DNQNLAENEC VYWPSKEEPM
NCEGFTVSMI SEDCMCLSNE ENLIIQDFIL EAMQDDYVLE VKHYQCPKWP NPDSPISKTF
ELINIIKEEA TTKDGPVIVH DEHGGVTAGT FCALTTLVHQ LESENSIDVY QTTKMINLMR
PGVFTDIEQY QFLYKAILSL VGTREEENPA TTVDSSAVLV DGNNAAESLE SLV
//
