ID H2ZYN2_LATCH Unreviewed; 197 AA.
AC H2ZYN2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002503.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01230998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01230999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01231002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYN2; -.
DR STRING; 7897.ENSLACP00000002503; -.
DR Ensembl; ENSLACT00000002523.1; ENSLACP00000002503.1; ENSLACG00000002234.1.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_1383763_0_0_1; -.
DR InParanoid; H2ZYN2; -.
DR OMA; ICPREXF; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002234; Expressed in post-anal tail muscle and 3 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0001565; F:phorbol ester receptor activity; IEA:Ensembl.
DR GO; GO:0021623; P:oculomotor nerve formation; IEA:Ensembl.
DR CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035840; Chimaerin_SH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF1; N-CHIMAERIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 61..129
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 164..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 197 AA; 23211 MW; B730D51090DAD2B0 CRC64;
MHKTNCKLYL YKPLNVENDE YRPPVWKSYL YQLQQEAPHP RRITCTSEVE NRPKYYGREK
RFHGMISREE ADQLLSVAEG SYLIRESQRQ PGTYTLALRF GNQTKNFRLY YDGKHFVGEK
RFESIHDLVT DGLITLYIET KAAEYIAKMT INPIYEHIGY TTLNREPTPK KHMPPLKDTQ
DGKDCREGDE IGEKRVS
//
