ID H3A246_LATCH Unreviewed; 920 AA.
AC H3A246;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Aryl hydrocarbon receptor 1b {ECO:0000313|Ensembl:ENSLACP00000003717.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003717.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003717.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01069809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A246; -.
DR STRING; 7897.ENSLACP00000003717; -.
DR Ensembl; ENSLACT00000003750.1; ENSLACP00000003717.1; ENSLACG00000003308.1.
DR eggNOG; KOG3560; Eukaryota.
DR GeneTree; ENSGT00940000154486; -.
DR HOGENOM; CLU_010044_1_0_1; -.
DR InParanoid; H3A246; -.
DR OMA; QINTEST; -.
DR TreeFam; TF352074; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0098531; F:ligand-activated transcription factor activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd11436; bHLH-PAS_AhR; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR033348; AHR_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF18; ARYL HYDROCARBON RECEPTOR 1B; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 5..58
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 99..162
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 411..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 102355 MW; C27E8E6D998F3709 CRC64;
VKPPMPDGVK SNPSKRHRDR LNLELERLAS LLPFPDEVTS NLDKLSILRL SVSYLRAKNF
FSVALKSHSC VEGAEGSGGH DNSKATGLAE GILPEGELLL QALNGFVLVV TVEGLIFYSS
HTIQDYLGFH QTDVMHQSVF DLIHTEDQLE FRRNLHWALN PTSHSGHSSH VSELGEKTPG
PTVVTYSPDQ LPPENSSFLE RSFVCRLRCL LDNSSGFLAL NLQGRLKFLH GQNKQLEDGA
PVPPQLALFA IATPLQPPSI LEIRTKNMIF RTKHKLDFTP LACDAKGRVL YNTTESSVRL
YHRHYRKVRV CISVYLYHRH CRKVRTLQKG VVRFHLVGGA NSSWKGANLC SKCTMWCFSR
RDITVKSTVP LTSPDEEGGE HLRKRSMHLP FAFATGEALL YQTSYPIPAF PDPFQPKGKS
SKSKKRSHNK PEKEQKNIDP NSLLGAMMRQ DESVYVSRPA PEPKYSLNSS FFNERGLSCI
PGTEADSWNS FPNGGNRLNQ SLVGYGQVDP LLSTLSSLSI NNEDNCSNNE LFGALENLGL
NAEDLELLLL DERMMRIEVD PDYIPSLNDL LTNSEILSYV HDSLVTRNDE GQLGSQQRYT
SVDPVKNSSK PTGMYPTLMQ DRPPQYFSQQ SLKTQQQQQH QLISHLSQEP TMTFQNKKNQ
QHLQASQGQT PSHHQPTMEP HHQQSGQQLG PSVRAQCELQ PPEMYQLPQA EVQLQLQSQC
QLKQNINQHP VINGIQQILT NNQWQDYSSK PVADHLVGLS AHTGGCDIGK EVASQVPSAG
VSIAGFHMSG MSNMEFIVNS GTQEDLAPYQ AFLSTASYQK QLVPAPVGYE YQPENSLDQF
LDISSGQQQI GMDSYGICPP SISKDNTQKA SDSSCVLMNA NMGYPGPCLL LNGNPGLPLD
KPHPCTEALP NHPSDSSFYL
//
