ID H3A2I5_LATCH Unreviewed; 891 AA.
AC H3A2I5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Synuclein alpha interacting protein {ECO:0000313|Ensembl:ENSLACP00000003856.2};
GN Name=SNCAIP {ECO:0000313|Ensembl:ENSLACP00000003856.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003856.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003856.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01253556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01253557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01253558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01253559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006013236.1; XM_006013174.2.
DR AlphaFoldDB; H3A2I5; -.
DR STRING; 7897.ENSLACP00000003856; -.
DR Ensembl; ENSLACT00000003891.2; ENSLACP00000003856.2; ENSLACG00000003433.2.
DR GeneID; 102347785; -.
DR KEGG; lcm:102347785; -.
DR CTD; 9627; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00390000001485; -.
DR HOGENOM; CLU_012404_0_0_1; -.
DR InParanoid; H3A2I5; -.
DR OMA; SQTQYCV; -.
DR OrthoDB; 5401710at2759; -.
DR TreeFam; TF329095; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Gene3D; 6.10.250.750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040133; SNCAIP.
DR InterPro; IPR032027; SNCAIP_SNCA-bd.
DR PANTHER; PTHR22882; SYNPHILIN-1; 1.
DR PANTHER; PTHR22882:SF3; SYNPHILIN-1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16700; SNCAIP_SNCA_bd; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT REPEAT 420..452
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 476..517
FT /note="Synphilin-1 alpha-Synuclein-binding"
FT /evidence="ECO:0000259|Pfam:PF16700"
FT REGION 36..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 97859 MW; 2E06454FD3005CA5 CRC64;
MAVSNSNWSC AVSTLIGTGQ KPTGIADVYS KFRPVKRVSP LKHQPENTEN EDSSVQQDQK
EDYHDQKEDY HKGDVSENTP QPSSQCLGDR QGFKAKEVGA STLLGDLEHY DLDMDEILDV
PYIKSNQQLT PFTKVAPEKR ILGVCSSGKG HGNKTCSVVS PENLPVSATQ FCVLSPVKSS
ELRKAHAIVP DQHKHSAGGL ELSQALVKCG SIHERETQSV GFLNRTCADS HVHKTDKTMP
NCQPRTFHLQ MTTTDSKLDE VNSNTNWNTR GGPGERNEDL KKVKSILNIV KEGQISLLPH
LAVDNLEKIH DENGNNLLHI AASQGHAECL QHLTSLMGED CLNERNNEKL TPAGLAIKNG
QLECVRWMVS ETEAIAELSC CKDHPSLIHY AACYGQEKIL LWLLQFMQEQ GISLDEVDQY
GNSAVHIASQ HGYLGCIQTL VEYGANVTIH NQAGEKPSQS AEHHGHTTCS RYLVVVETCM
SLASQVVKLT KQLKEQTAER VTLQVHLQHL LEAQREESGS LPTSPSSPLI SPGSSRPEQK
TANLNHSALQ KIKTSRTSEA LQNVTNLGAP NKNLLKQKDE DSDKILRQLL GKEISENVCT
QEKLSLEFQK GQQQQEGVSA VPKVLKRIPA EKRELKLARL RQIMQRSLSE SDTDSYNSED
QKSTPVKKAD KPRPQPIVEN MECTESLQLM IKKHTSAAGR RFPFSVRSSK SADGHSSSPT
SESSDPDYES HYQAGSVSRT QPAGDSSQSG SDGAGSQKVT TSPKSALKSP SSKRRTSQNL
KLRVTFEEPV VQLEQAEFDA CNSGDKESDR AFPPAPPSAE SGDSWKRPFG TFRSIMETLS
GNQNNNNNLH AATAMKTSAT LPLSPLGRKT AEMRANAVFP TKIKNKTVSV V
//
