ID H3A3N6_LATCH Unreviewed; 598 AA.
AC H3A3N6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=GALNT17 {ECO:0000313|Ensembl:ENSLACP00000004257.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004257.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004257.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936,
CC ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
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DR EMBL; AFYH01014429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01014438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A3N6; -.
DR STRING; 7897.ENSLACP00000004257; -.
DR Ensembl; ENSLACT00000004295.1; ENSLACP00000004257.1; ENSLACG00000003791.1.
DR eggNOG; KOG3736; Eukaryota.
DR GeneTree; ENSGT00940000156014; -.
DR HOGENOM; CLU_013477_4_0_1; -.
DR InParanoid; H3A3N6; -.
DR OMA; EENDAKY; -.
DR TreeFam; TF313267; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000003791; Expressed in pharyngeal gill and 3 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF38; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 17; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 466..594
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 598 AA; 68361 MW; 5DC401DAE73DECB4 CRC64;
MASLRRVKVL LVLNLVAVAG FVLFLTRCRP INIKAGEPIH GIHSRTDLSN LTTKGSSPMQ
EAVLKRLTLL EDIVYRQLNG LSKSLGLIEG YGGRGRNGLP STLSPEEEIK AQGPHEKYGY
NAYLSEKISL DRSIPDYRPN KCKELKYPKD LPQISIIFIF VNEALSVILR SVHSAVNHTP
AHLLKEIILV DDNSDDEELK EPLEEYVHKR YPGLVKVVRN QKREGLIRAR IEGWKAASGQ
ITGFFDAHVE FTAGWAEPVL SRIQQDRRRI ILPSIDNIKQ DTFEVQRYEN SAHGYSWELW
CMYISPPREW WDEGDPSAPI RTPAMIGCSF VVNRKFFGEI GLLDPGMDVY GGENIELGIK
VWLCGGSMEV LPCSRIAHIE RKKKPYNNNI GFYTKRNALR VAEVWMDDYK SHVYVAWNLP
MENPGIDIGD VSERKALRKR LKCKSFQWYL DNVYPEMRRY NNTIAYGELR NSKAKDICLD
QGPPENHTAI MYPCHGWGPQ LARYTKEGYL HLGSLGTTTL LSDTRCLVDN KKSRYPQLLD
CEKVKHIHHK TWHFIQHGAI MNLGTGRCLE IENKSNFVIV VVLRSCTGQK WTIKNFIK
//
