ID H3A4T0_LATCH Unreviewed; 146 AA.
AC H3A4T0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004651.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AFYH01189993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A4T0; -.
DR Ensembl; ENSLACT00000004690.1; ENSLACP00000004651.1; ENSLACG00000004140.1.
DR eggNOG; ENOG502RWGV; Eukaryota.
DR HOGENOM; CLU_123498_0_0_1; -.
DR InParanoid; H3A4T0; -.
DR OMA; CLGFTIN; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR CDD; cd03714; RT_DIRS1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33050; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33050:SF8; RIBONUCLEASE H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..122
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 146 AA; 16685 MW; 22CA10625D449D9A CRC64;
FMTKIDLSNS FHSIPIAPRH CHFFLFHWKE ELWQWTCMVF GLASAPWVFT KILRPFAACL
RSQGVRLLVY LDDILLMGSS AERLQEQTEV AVHLLTALGF QVNRGKSTLT PTQSIEYLGF
VVCARSLTLA LPARKTAMAL LKCRKW
//
