ID H3A535_LATCH Unreviewed; 688 AA.
AC H3A535;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=CHM Rab escort protein {ECO:0000313|Ensembl:ENSLACP00000004756.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004756.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Rab GDI family.
CC {ECO:0000256|ARBA:ARBA00005593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01114361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01114370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A535; -.
DR STRING; 7897.ENSLACP00000004756; -.
DR Ensembl; ENSLACT00000004797.1; ENSLACP00000004756.1; ENSLACG00000004227.1.
DR eggNOG; KOG4405; Eukaryota.
DR GeneTree; ENSGT00950000182994; -.
DR HOGENOM; CLU_021695_4_1_1; -.
DR InParanoid; H3A535; -.
DR OMA; LDQNDYY; -.
DR TreeFam; TF320813; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004227; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IEA:InterPro.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR Gene3D; 3.30.519.10; Guanine Nucleotide Dissociation Inhibitor, domain 2; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018203; GDP_dissociation_inhibitor.
DR InterPro; IPR001738; Rab_escort.
DR PANTHER; PTHR11787; RAB GDP-DISSOCIATION INHIBITOR; 1.
DR PANTHER; PTHR11787:SF4; RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A; 1.
DR Pfam; PF00996; GDI; 2.
DR PIRSF; PIRSF016550; Rab_ger_ger_transf_A_euk; 1.
DR PRINTS; PR00893; RABESCORT.
DR PRINTS; PR00891; RABGDIREP.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT REGION 136..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 75824 MW; E35353231263D80C CRC64;
LLERGPCLYH CVVLALGLQE SILAAACSRI GRRVLHVDRR SYYGGNWASF TFSGLLSWIE
EYKQGSVVSE ETSTWSSEIQ ENEEAILLNK AADRTITNVE VFCYVSADSE EGGEVGEAGA
LEKQLQTLAC AAGTENIDPS ETENQEGQSD AAPEGELPSE HPKASDLVSS TQEEDPSALS
LEGNQSVSGA GDQAPAAELP KVPEPKKKAL TYAEIVKGGR RFNIDLVSKL FYSRGTLVDL
LIKSNVSRYA EFKNVTRILA FQDGKVEQVP CSRADVFADK QLTVVEKRML MKFLTFCMEY
EQHPEEYSDF KEKTFSEFLR TKKLTGSLQH FVLHSIAMVS ESASIMDGLK NTQHFLQCLG
RYGNTPFLFP LYGLGEIPQC FCRMCAVFGG IYCLRHSIQC LVIDRDSKRC VALLDRCGEP
VFNPLVVDQR TSLNPRCNLK QRREISRAVL ITDRSVFKAD SNQQVSLLTM PPSEGRSAVR
VIELSSSSMT CMPGTYLVHL TSPSVRSAKE DLEPIVSQLF IQYSEDDTGC ALNTEEEEKP
RLLWALYFNM RDSSGVDRSL YEGLPDNVYV CSGADPALGS DCAVKQAESI FCQLFPEAEF
CPPAPNPEDI VYDADGSQPG DAGFGTPVEA EAKPEEDAAH GEEREGETAE TKEEGSGTRK
EEEVETLEPQ TETCSSADPT PPNKTEQA
//
