ID H3A5I1_LATCH Unreviewed; 755 AA.
AC H3A5I1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
GN Name=SLC26A5 {ECO:0000313|Ensembl:ENSLACP00000004902.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004902.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004902.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AFYH01064444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A5I1; -.
DR STRING; 7897.ENSLACP00000004902; -.
DR Ensembl; ENSLACT00000004945.1; ENSLACP00000004902.1; ENSLACG00000004358.2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR InParanoid; H3A5I1; -.
DR OMA; ICWGLVD; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004358; Expressed in chordate pharynx and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 96..123
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 181..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 246..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 416..435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 472..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 530..727
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 755 AA; 83162 MW; 8AC74A653DF66CD0 CRC64;
TETEDVLTRP ESYHVDRPIY SEESFQGQLH KRVKKPQTIG QKVSQHFRCS SKKAKSFLYR
FIPILKWLPQ YPVKEYLLGD IISGLSTGVM QLPQGLAYAL LAAVPPVFGL YSSFYPVFLY
AFFGTSRHIS IGTFAVISLM VGGVAVRVAP DEMFSISEGN STNFTELAEK YEARDAMRVK
VAAVVTFLAG IIQFFLGLLH IGFVSIYLTE PLVRGFTTAA AVHVFVSQMK YLLGIKTSRF
SGPFSIIYSV IAVFSNITGT NVAALIIGMT CIILLLIAKE VNGRFKSKLP APIPMEIIVV
IISTGVSAGM NLSQTYNVDV VGKIPTGLRP PVVPDFSLIP RIFGDALAIA IVGFSMAISM
AKIFAAKHSY TVNGNQELIA LGLCNFTGSF FQIFTVTCSM SRSLVQESTG GKTQIAGLLS
SFVVLLVILA IGYLFEPLPQ TVLAGIVMAN LKGMFKQFKD IPHLWRTSKN ELAIWIVAFV
SSVLLGLEYG LLVSVGFAIF TVIYRTQRNS PKYRILGQIP NTDIYCDTEE YEEVKEIPGV
KIFQANTSLY FANSELYVNA LKKKTGIDPY TILTAMKKAQ KKRENEEKSV PEQKKQAIIK
LSSNIEMGVE HELINEDTDL EISKNGGCVS SNADGQDSTF EELETFVRPA TETRSIILDF
TPVNFIDSVG AKMLKSIIKG HKEVGIDVYI SGCNRSVMED LNRLQFFKES ITRDLMFCTI
HDAVLHCQIK TSLSACESSV GEASEASVGQ VCPEK
//