ID H3A6Q2_LATCH Unreviewed; 335 AA.
AC H3A6Q2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005323.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005323.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AFYH01117130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A6Q2; -.
DR STRING; 7897.ENSLACP00000005323; -.
DR Ensembl; ENSLACT00000005370.1; ENSLACP00000005323.1; ENSLACG00000004732.1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT01100000263560; -.
DR HOGENOM; CLU_000384_33_7_1; -.
DR InParanoid; H3A6Q2; -.
DR OMA; LISPERM; -.
DR TreeFam; TF330171; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR33064:SF29; LRRGT00076; 1.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 19..200
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 335 AA; 37961 MW; 2FB99C8602F322F8 CRC64;
YPIPQEAVPH IQQVIDSLLQ QSIIRPCRSI CNSPIWPVRK PNGSWRLTID YRRLNSVTPA
MAPVVADITQ LTTKLQPTFT HFTVLDISNG FWSLPLHSDC QYKFAFSFEG VQYTWNCLPQ
GFHNSPALFH LAMKQALKSF PFPSNLIQYV DDLLLASADF TEHLQHLEAL LQCLQQAGLK
VNPDEAQLCL SQVSFLGVTL SSKGRSLDQH KLRVILSLPL PTDVTSLRSF LGMCNFMRMF
VYDFAAICKP LYSLFKTDTP FNWQPIHTEA VTSLKLALTS APVLMAPDYS LPFHLFFSFS
FPALAAVLME QKYTLCEMVL LTAHWALQHF LYLTG
//
