ID H3A703_LATCH Unreviewed; 360 AA.
AC H3A703;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=GMPPB {ECO:0000313|Ensembl:ENSLACP00000005424.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005424.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005424.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; AFYH01217350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010396.1; XM_006010334.2.
DR RefSeq; XP_014352770.1; XM_014497284.1.
DR AlphaFoldDB; H3A703; -.
DR STRING; 7897.ENSLACP00000005424; -.
DR Ensembl; ENSLACT00000005472.2; ENSLACP00000005424.2; ENSLACG00000004826.2.
DR GeneID; 102359278; -.
DR KEGG; lcm:102359278; -.
DR CTD; 29925; -.
DR eggNOG; KOG1322; Eukaryota.
DR GeneTree; ENSGT00940000158909; -.
DR HOGENOM; CLU_029499_0_0_1; -.
DR InParanoid; H3A703; -.
DR OMA; GPNCWIC; -.
DR OrthoDB; 5486038at2759; -.
DR TreeFam; TF300718; -.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004826; Expressed in pelvic fin and 5 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..233
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 360 AA; 40213 MW; B79497B03A218973 CRC64;
MKALILVGGY GTRLRPLTLS VPKPLVDFCN KPILLHQVEA LVKAGVSHVI LAVSYMSEML
EKEMKEQEQR FGIRISLSHE KEPLGTAGPL ALARKLLTDN SDPFFVLNSD VICDFPFVDM
IRFHKHHGKQ GTIVVTKVEE PSKYGVVVYE AETGRIHRFV EKPQVFVSNK INAGMYIFNP
TLLDRIQLRP TSIEKEIFPV MAQEGQLYAM ELQGFWMDIG QPKDFLTGMC MYLQSMRQKT
PEGLHTGPGF FGNVLVDPSA KIGENCNIGP NVTIGPGVVI EDGVRIKRCT ILKGSRIRSH
SWLESCVIGW NSAVGQWVRM ENVTVLGEDV IVNDELYLNG ANVLPHKSIS DSVPEPRIIM
//
