ID H3AC16_LATCH Unreviewed; 649 AA.
AC H3AC16;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=X-ray repair complementing defective repair in Chinese hamster cells 1 {ECO:0000313|Ensembl:ENSLACP00000007187.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007187.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AFYH01216430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01216439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AC16; -.
DR STRING; 7897.ENSLACP00000007187; -.
DR Ensembl; ENSLACT00000007247.1; ENSLACP00000007187.1; ENSLACG00000006378.1.
DR eggNOG; KOG3226; Eukaryota.
DR GeneTree; ENSGT00390000004140; -.
DR HOGENOM; CLU_030026_0_0_1; -.
DR InParanoid; H3AC16; -.
DR OMA; PEWIYAI; -.
DR TreeFam; TF101201; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006378; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR CDD; cd17725; BRCT_XRCC1_rpt1; 1.
DR CDD; cd17707; BRCT_XRCC1_rpt2; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR045080; BRCT_XRCC1_rpt1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002706; Xrcc1_N.
DR PANTHER; PTHR11370:SF6; DNA REPAIR PROTEIN XRCC1; 1.
DR PANTHER; PTHR11370; DNA-REPAIR PROTEIN XRCC1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF01834; XRCC1_N; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 338..426
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 554..645
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 228..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 72314 MW; 774E9696E851400A CRC64;
SLTFGGGVAF SQDMPEIRVK HVVSCSSEDS VHKAENLLKA DTYRKWKAGK PGEKQVSIIL
QVILSCPSLV ILEHCVGSRP SWRGRNESIE VLVVTSSFMS PTESRNATNL NRVRMFGPDK
LVKAAAERKW DRVKIICTQP YNKNLAYGLS FIRFSSPPED NEVSPVTSSL KLTKLGQFKV
KEEEPGSSAM RPGSLFFSRG TKSLVSPSKD DKPAPSFAVA TLHSAGDAAL DTSPTPAEKA
TTAVSSSAAS PKESTLGKKR FEFPKEKQSG PPAKKPASRG ESSESPRPKP PRPPESSAPA
PAPAARSMER QQQKKEVTKV KKKKKKKKKQ KEESSSVEFG RLLEGTVFVL SGFQNPFRGE
LRDKALAMGA KYRPDWTHDC THLICAFANT PKYSQVKSLG GTIVRKEWVL NCHKRKERIS
CKRYAAGNPR SSPSNSNHAA KGNSPKREAS RQTTKEEEEE RPGTSKTEWR SWQQQEEEDY
GGLTDEDPPD GGEGEERQHG NDSEGDTEDE LIRAQEENRR KQGSKTTTGA EDDPYGGSTD
ENTEGEEVDL PIPELPEFFA GKHFLLYGEF PNNEKRLLTR YIVAFHGVLE EYMNESVNYI
VTAQEWDDKF EEALTENSNL SFVKPRWIYM CNEKQKLVPH QPFMVVPLA
//
