ID H3ACX1_LATCH Unreviewed; 868 AA.
AC H3ACX1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102346768 {ECO:0000313|Ensembl:ENSLACP00000007492.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000007492.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000007492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01208804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ACX1; -.
DR Ensembl; ENSLACT00000007555.1; ENSLACP00000007492.1; ENSLACG00000006643.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H3ACX1; -.
DR OMA; GTCTCAV; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..868
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579461"
FT TRANSMEM 605..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 601..865
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 868 AA; 96533 MW; 7313090A5D502F37 CRC64;
LCKMMLAIIL FSLLLSAPVS EMTQQGCTLH SLNVKGYIED GDIIIGGIFP LYYSKMFPDA
PFTEMPELVY CETFRLRHYR WVQGMVFAIE EINKNKQLLP NISLGFAIYA SCNVAARAIK
GIMWMVTGQE ETIPNYRCDL QAPLAAIVGG GASSMSIPMA RISGIYKYPQ ISYASSVVLL
SDKHEFPSFF RTIPSDEFHS MGLARLVMHF GWTWVGLIAE DSNYGLQGIL SLEEEIVKGG
GCVAFSKIIP QVYNKNALHQ IIENIKHSMA NVFVIISNDA SANLLMEEVE RQNITGKVWI
ASDGWSPLSL YSENKFLKTL IGTIGIMTRQ GEIPGFQEFL FNVHPSKSPN DTFIKEFWED
AFGCKWPDTD SQTATNELSK GSTLCTGTEK LNELNNAFVD ASNLRLTYNI YNAVYAAAYA
LHDLYSCKPG KGPFANGSCA NIHDFEPWQL LHYVKNVHFI NTAGKEVFFD ENGDPPPAYD
ILNWQLLSDG SAKNVRIGMI EFSTTQGPHL IINESAIMWN GGQTQIPRSV CTESCPPGYR
KAIRPGKPIC CFDCIMCSKG EISNQTDSSE CMKCPDDHWS NERQDTCIPK PTEFLSYEDS
MGTTLAAISI FCAVISVTVL YIFITYRDTP IVKANNRELS YFLLLALVLC FLCSLIFIGK
PQTWTCMLRQ TAFGIIFALC VSCVLAKTIM VVIAFNATKP NSNLRKWVGT KVPNTVAFIC
TIIQVIICIS WLAISPPFPE QNMTSQTGMI IIECNEGSTI AFWCVLGYMG LLAVISFVVA
FLARNLPDSF NEAKFITFSM LVFVSVWLAF IPAYLSTRGK YMVAVEIFAI LASGAGLLTC
IFSPKCYVII LRPDMNTKEH LMGRGTPS
//
