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Database: UniProt
Entry: H3AGJ3_LATCH
LinkDB: H3AGJ3_LATCH
Original site: H3AGJ3_LATCH 
ID   H3AGJ3_LATCH            Unreviewed;      1326 AA.
AC   H3AGJ3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0000313|Ensembl:ENSLACP00000008764};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008764, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000008764}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000008764};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000008764}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000008764}.
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DR   EMBL; AFYH01125465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01125474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000008764; -.
DR   Ensembl; ENSLACT00000008833; ENSLACP00000008764; ENSLACG00000007747.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; H3AGJ3; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0016048; P:detection of temperature stimulus; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   GO; GO:0050951; P:sensory perception of temperature stimulus; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029583; TRPM3.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF7; PTHR13800:SF7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    556    574       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    586    603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    623    644       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    702    727       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      496    736       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      830    884       TRPM_tetra. {ECO:0000259|Pfam:PF16519}.
SQ   SEQUENCE   1326 AA;  152682 MW;  C5029CDADD7CBAC4 CRC64;
     DQLTIELNHL FIYFGRHISF LYITILALIK QKSYCITVFR MGSEGHQDID LAILTALLKG
     ANASAPDQLS LALAWNRVDI ARSQIFIYGQ QWPVGSLEQA MLDALVLDRV DFVKLLIENG
     VSMHRFLTIS RLEELYNTRH GPSNTLYHLV RDVKKREYPG FGWIYFKGNL PPDYRISLID
     IGLVIEYLMG GAYRCNYTRK RFRTLYHNLF GPKRKRSLEK TQMRYIIPLL KHRRTFLRLE
     KTIPSQINQP KAFTFKDHEP CLSTPIPKGY MMPLYITSHI QSSLCKALIC IPLVFAQIHI
     FRLNPLESQK NKQTKPTKIL DAIVKTCHSK LNIQIKIKLY FYNVLSYNTM VTFGLFVFAR
     YRGILKFKVK QIIADMHIKF MNNNNNNNLR VILGILIPPS ILSLEFKYKD EMSYLPQGQE
     DQLNEKEPEE PEKPAKEKEE DDMEFTAMLG RRNRESRRKK DEEEGPSRHR LIPFGRKIYE
     FYNAPIVKFW FHTLAYIGYL MLFNYIVLVK MERWPSVQEW IVISYIFTLG IEKMREILMS
     EPGKLLQKVK VWLQEYWNVT DLMAILLFSI GMVLRLQETS RSYGRVIYCV NIIYWYIRLL
     DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA RQAILNPSED PSWKLAKNIF
     YMPYWMIYGE VFADQIDPPC GQNITGEDGK VIQLPPCKTG AWIVPAIMAC YLLVANILLV
     NLLIAVFNNT FFEVKSISNQ VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MVCQHLCCRW
     RKHEGDQEDR DYGLKLFITE DELKKVHDFE EQCIEEYFRE KEDHFNSSND ERIRVTSERV
     ENMAMRLEEV NEREHFMKAS LQTVDIRLTQ LEETIGRMAS IMERLSGVDK GEVTKIRSRA
     SSDCTDTAYI MRQSSFNSQE GNAYKLPETT DPIGEEIMSP TSPTLMPRLR SHSFYAMGAK
     DKGGLEGLEG FFKERPVSLH RATSSQSVTA ARETKATSQP AKILPVNQDP KKLSSCIDIF
     VSTSDEMQTA TEAAEKSLKV PVVRDQSFHS EIMAAVLASQ AHSTGAGPVG KYPDGNGVFE
     ETTTTDTPML RSGSTHFIDS QSQWDIDPPS YQILERSKSS RYLATTSFFD DTSMVKSHSF
     MFSPTRGYFS NLGVPVKTAE YTSITDCIDT RCVTASQTSS EHSTSPGNHG GKAEDMVISH
     PEREAELSHP SSDNEEHEGE ARDRHEDGSL SSQNANSNRP VSNNISVPKM ERANSYSAEE
     PNMLYAYTKK SYSISDKLDT RQRNLTGMRN PFQRSKSAKP EGKSESLSMR RLSKTAAFRS
     FESKHN
//
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