ID H3AGQ7_LATCH Unreviewed; 1464 AA.
AC H3AGQ7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=FYVE and coiled-coil domain containing 1 {ECO:0008006|Google:ProtNLM};
GN Name=FYCO1 {ECO:0000313|Ensembl:ENSLACP00000008828.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000008828.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000008828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01147567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01147576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000008828; -.
DR Ensembl; ENSLACT00000008897.1; ENSLACP00000008828.1; ENSLACG00000007800.1.
DR eggNOG; KOG1729; Eukaryota.
DR GeneTree; ENSGT00940000154044; -.
DR HOGENOM; CLU_004445_0_0_1; -.
DR InParanoid; H3AGQ7; -.
DR OMA; ELGMSIC; -.
DR TreeFam; TF341788; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007800; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15726; FYVE_FYCO1; 1.
DR CDD; cd17698; RUN_FYCO1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047337; FYVE_FYCO1.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047336; RUN_FYCO1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46753; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46753:SF2; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..171
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1212..1270
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 258..306
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 363..883
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 965..1186
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1464 AA; 168690 MW; DEBE0C14AC2194E7 CRC64;
LAMAVSSGEN QLQRIIKDLQ GAATDLNIEF KENGEPITDD SENLHKFSFK LEYLLQFDQK
EKTTFLGSRK DYWDYFCDCL AKIKGANDGI RFVKSIPELK TSLGKGRAFI RYSLVHQRLA
DTLQQCIMNV KVTSDWYYAR SPLVKPHLNS DIINHLYELN EVQFDVASRG HDLDSAWPTF
ARRTLGSLSS PAHSWKPPSR SSSISSLLSS YSQKTFRLNP YTSVIVFLTF LFFFFLHGYS
IQQVHEFPSS PDMNSSLAAE QLETLDELRI ELDQSDLKHK QMQERIQQLE IEKQELQKLT
VLQEELQKCL QTLELSSSEK QKEYQTAVMQ LETSNKGSAS ELMALTQELE TAKVSEKTKE
CCIDELKIKL SFAEQKNLEL ISRIEEILNE KGQQTANHYD SALKIHELLD KLNEAEKEKS
ELQKVSSEQQ TQLEKLAQDL KERDAIVKEH EEKVSAFSLN SAEENTNLVE ELEKVNALLQ
GNLTLKENET ANLQLQLQDS SKNFELLEKQ YEEELEEARQ EKEESQKMHE NTKRSFEEQL
LNMNNTTRNL ESQKSKLVCD KDNLNKTVQA LEEKITKQRL AVEEISAENE KLQVQNQKLQ
QALKKCEGEN KELVGSGASL ETEVIRLKAS EKQLQSQIDD AMVTVDEKEK KLRDENRTLD
ESLQNVIRQN KTLEDTLKKL QHDHDNLKGE ISSLNSSLSL LQTEHRNAMQ HVLELERNLL
VLEDNEETLK QQATEQDSVL QEKESYCKQL LERLERSEKK VSNLEKEKLS LEKTCMQQSK
LIESITAEKA SVEKLQLEQR ADQEKESQEI NSRLSMTEKQ LEVRINEVSR LQQEVISLRT
NLQQATEDQE KCQDKLNLSE RSLEEYRLLV EQLKEQIESL NRSHVEEVVL FKEREELLRK
EKEEEACHRA ELETSLLSLQ QELSTFKQYA EKTKLENAET KDLLHRTNTE MAELGIQICA
LTSEKVDAKQ NLAEAAARIQ ELSDMLVEER EKMNLEMCSL GQENESLHEK LGLSDGLAST
VKDLQAKLDK AEKLGKNLQE TTKEEISAIK FQMSTEVMNC QSKLKTVSEE LEDMKRELDE
RQTQISSLEE QLALLQALKT SLSQDVDQKS EQVQNKDEEV KLLEENLERT QKELEEAQKQ
IRESCDKLEE MQADKDRNEL KLLAELDDLN RTKTYLEERL IELIRDKDVL WQKSDALEFE
QKLRAEERWL GDKEVNHCLD CKSQFTWWLR RHHCRLCGRI FCYYCCNNFA MTKHSGKKER
CCRDCFLQHG AISQRISEPG SPSEESSLDE SPLLQAPMSL QAGSVTVTDE VSKQDDAAFD
IITDEELNQV KECDSLTQTE GQAQYTRELN EASHAMTPEE PSELMPVMQD AEICLLKSGE
LTLRLPLTVE DIFQFGESNK ELFIKSSNYS VIPITVEETG LKINWLFSSD PKSISFSVVF
QESAETPLEQ CKVYLQEGVV PLGC
//
