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Database: UniProt
Entry: H3AHA4_LATCH
LinkDB: H3AHA4_LATCH
Original site: H3AHA4_LATCH 
ID   H3AHA4_LATCH            Unreviewed;       511 AA.
AC   H3AHA4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Transmembrane phosphatase with tensin homology {ECO:0000313|Ensembl:ENSLACP00000009025};
GN   Name=TPTE2 {ECO:0000313|Ensembl:ENSLACP00000009025};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009025, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000009025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000009025};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000009025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000009025}.
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DR   EMBL; AFYH01135145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01135146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01135147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01135148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01135149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01135150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000009025; -.
DR   Ensembl; ENSLACT00000009094; ENSLACP00000009025; ENSLACG00000007968.
DR   eggNOG; KOG2283; Eukaryota.
DR   eggNOG; COG2453; LUCA.
DR   GeneTree; ENSGT00760000119113; -.
DR   InParanoid; H3AHA4; -.
DR   OMA; YFWFNTS; -.
DR   OrthoDB; EOG091G09VG; -.
DR   TreeFam; TF354329; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:Ensembl.
DR   GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IEA:Ensembl.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   InterPro; IPR029023; Tensin_phosphatase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   Pfam; PF00782; DSPc; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     56     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     90    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      192    368       Phosphatase tensin-type.
FT                                {ECO:0000259|PROSITE:PS51181}.
FT   DOMAIN      374    511       C2 tensin-type. {ECO:0000259|PROSITE:
FT                                PS51182}.
SQ   SEQUENCE   511 AA;  58745 MW;  2E51C390BBF2F593 CRC64;
     MSSIKYNLES DSEGVNSFRN GEDAKVEIDD GKVEINEPDT WYSTIRKAVA PFVLSFGFRI
     FGLVLIIIDI ILVIVDLATP EKSIAVRDAI EITSLVISFF FLIDVLLRIF VEGFRVYFQS
     KLNILDAVIV IVTLIITMVY AFSDFSGTNL IPRVVNFFRA LRIIILIRIF RLASQKKQLE
     KATRKMISEN KRRYQKDGFD LDLTYVTVTK VQNQFPGSGL ETFGRNFLEE VARFLDTKHK
     DHYKVYNLCS EKGYDPKYFH YRVERVFIDD HHVPALEDML KFTASVREWM AEDERNIIAI
     HCKGGKGRTG TMICTWLIDS DQFESAKESL DYFGERRTDT SVSSKFQGVE TPSQSRYVGY
     YEIMKAQNRQ LPPEKNLTIK SIRIHSILAG VGRSNGSDLK VQISAKQQVV FQCICATQEN
     CKLFFDAESN AAVIRLEGCP VISGDVKVKF ESSAGLPKGY DDCPFYFWFN TSFVKNSRLY
     LSREELDNPH KPKTWKIYKE KFAVELKFDE P
//
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