ID H3AIJ7_LATCH Unreviewed; 582 AA.
AC H3AIJ7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=EWS RNA binding protein 1 {ECO:0000313|Ensembl:ENSLACP00000009468.1};
GN Name=EWSR1 {ECO:0000313|Ensembl:ENSLACP00000009468.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009468.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TET family.
CC {ECO:0000256|ARBA:ARBA00008448}.
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DR EMBL; AFYH01201810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01201811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01201812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01201813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AIJ7; -.
DR Ensembl; ENSLACT00000009540.1; ENSLACP00000009468.1; ENSLACG00000008350.1.
DR GeneTree; ENSGT00940000154191; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000008350; Expressed in pectoral fin and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd12533; RRM_EWS; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR034869; EWS_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034870; TET_fam.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23238; RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR23238:SF3; RNA-BINDING PROTEIN EWS; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 295..381
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 453..484
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 123..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 61124 MW; 8BA667D8CD11FFA0 CRC64;
MFSADYSAYS QAGAQQSYSS YAAQPAQGYA QTTQSYGQTY GTYAQPTDAT YTQAQTTAAY
GQAAYAAAYG QPPAAYTAPG APQSYTQPAQ GYSSTSGYDA TAAASSTTQA AYTAAAQPAY
GTQPAYPGYG QPPASTVTTP VRPPDGSKPV ESTPSQSNTT GYNQPNLGYG QSNYSYPQVP
GSYPLQPVNA PPSYPPSSYS SSTQPSTYDQ STYSQQGSYT QPTSYGQQTN YGQQQGSYGQ
QASSYPPQTG SYGQPPPSQY SQPSSGFGQP GPMEEMPEPE PGLNIMPEED EAENNTIYIQ
GLNEDVTIEE LADYFKHTGV LKINKRTGQP LINIYTDKES GKPKGDAMVS YEDPPAAKAA
IECFDGKDFQ GNKLKVSMAR RKPLMNSMRG GMPPREGRGG PLLRGAKGPS ITGNGTAPMG
RGGGRGGERG GGFPPRGLRG PRGGPSGGNM QHRAGDWQCP NPGCGNQNFA WRTECNQCKA
PKPDGFGPPP FPPMGGDRGR GGPGMRGGRG MDRGGPGPFR GGRGGDRGGF RGRGMDRGGF
AGRRGGPPME LMGGRGGGRR GGPPGKMDGK GDHRQDRRDR PY
//
