ID H3AIM4_LATCH Unreviewed; 1234 AA.
AC H3AIM4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Diaphanous related formin 1 {ECO:0000313|Ensembl:ENSLACP00000009495.1};
GN Name=DIAPH1 {ECO:0000313|Ensembl:ENSLACP00000009495.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000009495.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000009495.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; AFYH01064722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01064731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AIM4; -.
DR STRING; 7897.ENSLACP00000009495; -.
DR Ensembl; ENSLACT00000009567.1; ENSLACP00000009495.1; ENSLACG00000008375.1.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000159910; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR InParanoid; H3AIM4; -.
DR OMA; TPSIKMK; -.
DR TreeFam; TF315383; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000008375; Expressed in pectoral fin.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF4; PROTEIN DIAPHANOUS HOMOLOG 1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 80..447
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 781..1183
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1205..1233
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 473..525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1160..1206
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 47..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 139125 MW; 868ACDC4252A9DC2 CRC64;
MDRGGGGGGG GKDRKSRRNP DESSGGPVEG KKKFTLKRLM ADELERFTSM RTKKDKEKPN
VPHRLSSASY CEVPSPSLML TDVPDEAVLQ LFEQMLTDMN LNEEKQQPLR DKDISIKREM
VSQYLHTSKA GQSQKESSKS AVMYIQELKL GLRAEQLLSC LESLRVSLSN NPVSWVQTFG
TEGLTALLGF LKKLQDEHDE PHSSLDQRTQ HEIIRCLKAF MNTKFGIKTM LETEEGIMLL
VRAVDPRVPG MMIDALKILS AICILSTTDK MHERVLGALT ERAEMDDIER FAPLLQGLRS
SSSPQLKSAC MQLINALISQ SDELDFRIHI RSELMRSGLK KLLQVKELYV LENEELKVQM
TIFGEQGEED SEDLKDRLDD IRIEMDDAAE VFQYLLNTVK DSEAESYFLS ILQHLLLVRN
DYGARPQYYK LLEECTAQVV LHRNGYDPDF RCRPYKELDV DGIIDKMIDK TKVEKSEAKA
IELERKLDSE LTARHELQGE IRKKESDFEE RVTNLLKEKQ VLETEKGEVI TEKMKVQGEV
TRYKEEMTTP PLSKTRIEQT HLCVHAHAHT HTHTHTHTHT HTHTHLPGGP GMPPPPPPVL
GGPGMAPPLP PVSQAPSTLP KGVCVYENTE AGGFATSTTP PPENTEADLP PPPPALCVSV
CVHISPPTTS PVCFHLCTYL PPPPALCVSI SLPSLYTPSA PPFCSFSVCP VPPPPASGHH
IGVYSPPPTP PKKKKKKIPP FCPFHSFKKI SPPPPHTRLF PPAPSNLGST TRFVILKSFN
PKITYLAEVP REMANWWSKS KEMVMDLSLN CFLAPVKHTQ SESESTFIKL VSTWLGRSIT
KSQQEGTGEK KTTQKKKVKE LKVLDAKTGQ NLSIFLGSFR VSYQDIKKAI LEVNEKILTE
SMLQNLVKQL PEPDQLSALA ELKDEYDDLA ESEQFGVVIS TVSRLRPRLN AILFKLQFDE
QVNNIKPDIV SVTAACEETR NSETFAKLLE LILLVGNFMN AGSRNASAFG FNISFLCKLK
DTKSTDQKMT LLHFLAEVCE EQHPDVMRFP DELTHIEKAS KVAAENLQKN LVQMGKQISN
LEKDIKSFPP STDEEDKFVE NMTIFVQMSR EQYEKLALMH TNMEKLYEEL GEYFIFDPKK
VSVEEFFGDL SNFRSAFLQA VMENQKRKEA EEKIRKAKLA KEKAEKERLE KQKKKQLIDI
NEEEDETGVM DSLLEALQSG AAFRRKRGPR QAGK
//
