ID H3AL85_LATCH Unreviewed; 837 AA.
AC H3AL85;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010406.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010406.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AFYH01176858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AL85; -.
DR STRING; 7897.ENSLACP00000010406; -.
DR Ensembl; ENSLACT00000010485.1; ENSLACP00000010406.1; ENSLACG00000009168.1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT01100000263560; -.
DR HOGENOM; CLU_000384_9_9_1; -.
DR InParanoid; H3AL85; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR CDD; cd05481; retropepsin_like_LTR_1; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR PANTHER; PTHR37984:SF8; PROTEIN CBG26711; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 273..446
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 837 AA; 94745 MW; A41B39A5D819EBE4 CRC64;
AFGKISEFDS SVEEWPQHAE RLAQFFLAND IVDVGKKHAI LLSVCGVKMY SLIRNLTAPP
GEKTYDELVM LVRNHHNPPP SETVQRYKFN MCSRQAGEGV GALVAQLRGL SEHCNYGTTL
EIDLMLNSVN VKMEIDTGAS VSVIGEDMFQ GERSLNIKPT KSILRTFTGE QIPVMGTVDV
KVEYKGLPLL VVQGDRPALF GWNVHLLKSE HASMEALIGK YPTLTEDSLG TLKGVKGHFQ
VDPEAKPRFF KPRSIPYMLH EKVNAELERL QKEGIIEPVE FADWAAPIVP VLTADRKTVR
ICGDFKTTVN RIAKVNSYPL PRIEDLYAKL SGGKKFTKLD LKNVYLQIEL EEDSKKFVTI
NTQRGLFQYN HLSFGMSSAP AIFQWVVDNL LQGIPYICTY LDDIIVLGRE QNLNQVLERL
SKVGMWLNMD KCTFMEAEVT YLGYHINAEG LQPVAEKACA IARAPEPTNV HELGSYLGLL
NYYRRFIPNL STRLAPLYKL LNKNVHFTWG PVQAQAFQLS KGLLQSYEVL IHYDPNKELI
LSCEASSYGL GPVLSHRLQD GTERPISFAS QSLSPAKKCY LQLEKEVLAV VWGVKKFHVY
LFGRHFIIKN DHKPLQGLLN EEKPVPVLAA GRIQHWALIL SAHEQHSFQY KPGNNLGNEE
ALSRLPLPDM PGETPSPADV VGLLEFMDTS PIDVGCVKHW TDRDCWLSRV RSWPDSVGRE
EELCPYYSRR EELSIQKFFG GARVVIPVQG RSRVVDMIHE AHPGIVREYV WWPKIDQDLE
NKDAVYVINF SNCSCWLKGV ITRRTGPVSY LVELLDERVV CCHQDHLQTN QNHIKKE
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