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Database: UniProt
Entry: H3ALP2_LATCH
LinkDB: H3ALP2_LATCH
Original site: H3ALP2_LATCH 
ID   H3ALP2_LATCH            Unreviewed;       840 AA.
AC   H3ALP2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSLACP00000010563};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010563, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000010563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000010563};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000010563}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000010563}.
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DR   EMBL; AFYH01149316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01149325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000010563; -.
DR   Ensembl; ENSLACT00000010642; ENSLACP00000010563; ENSLACG00000009309.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H3ALP2; -.
DR   OMA; LGTQNFG; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    407    431       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    470       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    577    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    666       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    773    796       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   840 AA;  96100 MW;  3E6FD5BD042B8536 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDV SHCTPLAGGL RLLQRAQYEN
     IRTCDEFSLA LRFVEKEIKK ANIPILDTGE NPEVPFPRDM IDLEATFEKL ENELKEINTN
     QEALKRNFLE LMELKYILRK TQQFFDEMAD PELLEESSTL LEPSEAGRGA PLRLGFVAGV
     IHRERIPLFE RMLWRVCRGN VFLRQVEMDD PLEDPVTGAQ VHKSVFIIFF QGDQLKNRVK
     KICEGFRATL YPCPETPQER KEMAGGVNTR IEDLQMVINI QQSHLYRILQ AAAKNIRVWF
     IKVRKMKAIY HTLNLCNIDV TQKCLIAEVW CPVTDLDSIQ FALRRGTERS GSTVPSILNR
     MQTKQTPPTY NKTNKFTSGF QNIVDAYGIG TYREINPAPY TIITFPFLFA VMFGDFGHGI
     VLTMFALWLV IRESRILSQK SDNEMFNTVF SGRYIILLMG IFSIYTGLIY NDCFSKALNF
     FGSSWSVRPM FTKENWTEEV LHSHALLQVN PAVPGVFNGP YPFGIDPVWG SSLKDCCYTS
     SLVTKIFIVL GIYVMGLLML LMSLFDYNYF KKPLNIYLGF IPEFIFMVTL FGYLVILILY
     KWCAYDAVTS KDAPSLLIHF INMFLFNYSD SSNRMLYRGQ QQGLQSFLVV VALLCVPWML
     VAKPLVLRHQ YLRKKHLGTH NFGGIRVGNG PTEEDAEIIQ HDQLSTHSED ADEFDFADTI
     VHQSIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWT MVMHIGFNVK NLGGSLLLVV
     IFAAFATLTV TILLIMEGLS AFLHALRLHW VEFQNKFYSG LGFKFIPFSF ESILEGKFDD
//
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