ID H3ALT1_LATCH Unreviewed; 501 AA.
AC H3ALT1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Growth differentiation factor 5 {ECO:0000313|Ensembl:ENSLACP00000010602.1};
GN Name=GDF5 {ECO:0000313|Ensembl:ENSLACP00000010602.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010602.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010602.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AFYH01186272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ALT1; -.
DR STRING; 7897.ENSLACP00000010602; -.
DR Ensembl; ENSLACT00000010681.1; ENSLACP00000010602.1; ENSLACG00000009339.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160455; -.
DR HOGENOM; CLU_020515_0_0_1; -.
DR InParanoid; H3ALT1; -.
DR OMA; WHLTWLD; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035141; P:medial fin morphogenesis; IEA:Ensembl.
DR GO; GO:0035138; P:pectoral fin morphogenesis; IEA:Ensembl.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..501
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580013"
FT DOMAIN 378..501
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 91..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 55918 MW; 609A5D824FCA555D CRC64;
MKIPNIPPLL LSYLTWVCLN PALAVPNRSE PGQSGPGARQ GFLKVEGGDK IPLARAGTHR
VRSHGYGVGT PKAGAKTIGV HSGITLIGAH GTKSDISRHG TGPSTARKGV SQNRNPGVKK
GVPKVAYLGG KPPSKTGPIK RNTNGQKKVN APSAAVQRER KVVSKEPAVT PHDYMLSLYR
TLSAVERKGF NESLLQEAGL ANTITSFVDK GQDERSPLIR KQKYHFNISA LEKDGLLGAE
LRILRKRPLD TRRARSIGSI YSLKLFSCHT NKQPSVLLDS RTIDTLDTPK WEVFDIWKLS
KNFKNAAHLC FELEAIERGR PVDLRNLGFN RAGRQTKEKA LFLVFGKTKK RDLFFNEIKA
RSGQDDKTVY EYLFNQRRKR RAPLSTRQGK RTIKNPKARC SRKALHVNFK DMGWDDWIIA
PLEYEAYHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILYID
SANNVVYKQY EDMVVESCGC R
//
