ID H3AMG3_LATCH Unreviewed; 243 AA.
AC H3AMG3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Ribosomal RNA-processing protein 43 {ECO:0000256|ARBA:ARBA00030617};
GN Name=EXOSC8 {ECO:0000313|Ensembl:ENSLACP00000010834.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010834.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000010834.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; AFYH01159320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01159321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01159322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01159323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006005268.1; XM_006005206.2.
DR AlphaFoldDB; H3AMG3; -.
DR STRING; 7897.ENSLACP00000010834; -.
DR Ensembl; ENSLACT00000010914.1; ENSLACP00000010834.1; ENSLACG00000009536.1.
DR GeneID; 102366724; -.
DR CTD; 11340; -.
DR eggNOG; KOG1613; Eukaryota.
DR GeneTree; ENSGT00950000183130; -.
DR HOGENOM; CLU_038194_3_1_1; -.
DR InParanoid; H3AMG3; -.
DR OMA; RIWYQPP; -.
DR OrthoDB; 21598at2759; -.
DR TreeFam; TF320415; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000009536; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd11369; RNase_PH_RRP43; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR033196; Rrp43.
DR PANTHER; PTHR11097:SF9; EXOSOME COMPLEX COMPONENT RRP43; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 31..166
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 193..240
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
SQ SEQUENCE 243 AA; 26307 MW; 9202B4CBEB496891 CRC64;
MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTLNVG SITTADGSAL VKLGNTTVVC
GIKAELAVPP ADTPNKGYIV PNVDLPPLCS SRFRPGPPGE QAQVASQFIA DVIESSQVIL
KEDLCIEKGK LAWVLYCDIM CLDYDGNVLD ASMIALLAAL KNVQLPSVCI NQDTNLADVN
IKQKVPLSIH KHPVATSMAI FDDAIIIVDA TAEEEDLATG TVTIVTDEQE KLCAIHKPDC
PCF
//
