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Database: UniProt
Entry: H3AMW3_LATCH
LinkDB: H3AMW3_LATCH
Original site: H3AMW3_LATCH 
ID   H3AMW3_LATCH            Unreviewed;      1836 AA.
AC   H3AMW3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-SEP-2017, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSLACP00000010984};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000010984, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000010984}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000010984};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000010984}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000010984}.
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DR   EMBL; AFYH01139818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01139824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006003324.1; XM_006003262.2.
DR   RefSeq; XP_014348354.1; XM_014492868.1.
DR   RefSeq; XP_014348355.1; XM_014492869.1.
DR   STRING; 7897.ENSLACP00000010984; -.
DR   Ensembl; ENSLACT00000011066; ENSLACP00000010984; ENSLACG00000009665.
DR   GeneID; 102366443; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H3AMW3; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    365    384       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    404    431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    615    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    645    668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    725    753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    813    838       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1049   1067       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1088   1104       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1136       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1165   1191       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1312       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1371   1389       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1401   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1431   1451       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1488   1516       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1615       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    437       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      616    842       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      852   1043       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1047   1320       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1370   1625       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      428    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1836 AA;  209191 MW;  1AAB361A43BB73D2 CRC64;
     MAGLRVTPGP DMLRRFTRES LAEIEKRFAK KQADKAKKKH VELNEDLAPK PSSDLEVGKS
     LPFIYGDLPP ELIGVPLEEL DPFYSGERTF IVINRGKTIN RFSTTPALYL LSPFSSVRRG
     AIKVLIHSLF SFFIMITILT NCVFMTMSAP PPWAKNVEYT FTGIYTFESM IKILARGFCI
     DSFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTITVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRQKCVIW PPPFNDTWTD FDLGMGNDTF
     HNTTIYDSAA AYSNTTFDWD AYLNNEENFY FLDGQLDALL CGNSSDAGRC PEGFLCMKAG
     RNPNYGYTSF DTFSWAFLSL FRLMTQDYWE NLFQLTLRAA GKTYMIFFVV IIFLGSFYLI
     NLILAVVAMA YAEQNEATLE EAKQQEEEFQ RQLEQLKKQQ EEQAAKLHGS SGQHLSSKDS
     LASSKGQKRD MDTKSDDEQS GGEGRKMAND WNGRPVPSVV IDRVSTGEES ETIDREQEKT
     ASNHPSIDHL EEPTLQKRTA SIVSVVSNTM EELEEAHQKC PPWWYKFAYK FLIWDCCILW
     VKFKEIVKFI VMDPFVDLGI TICIILNTMF MAMEHYPMTP QFENVLSIGN LVFTGIFTAE
     MVFKIIALDP YYYFQIGWNI FDSIIVTLSL VELGLANVQG LSVLRSFRLL RVFKLAKSWP
     TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK NYKDCVCKIS SDCVLPRWHM
     TDFFHAFLIV FRILCGEWIE TMWDCMEVAG QPLCFIVFMM VMVIGNLVVL NLFLALLLSS
     FSADNLSASD DDNEMNNLQI AINRITRGVD FIKSLPVRLL QGIRRTDNED DDQKKEDYVL
     NHMDPVPESK SDFKPVDGVA SKEPHLADEV DQMSFMDNPS IAVRVPIAAA ESDLEIADEE
     MTSESETEDV KKKESDIGSS RCSTADYQAP EVVEEVVAEE EPENEDPEPC FTEGCIRRCP
     CLTVDITQGS GKLWWTLRKT CFKIVEHNWF ETFIIFMILL SSGALAFEDV YIERRRVVKI
     ILEYADKVFT YVFVVEMLLK WTAYGFKTYF TNAWCWLDFL IVDVSLISLT ANWMGYSELG
     PIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
     GKFYRCVNTT TGELFDVSMV NNKSDCFSLY DTGEVRWMNV KVNFDNVGFG YLSLLQVATF
     KGWMEIMYAA VDSREVEEQP SYEINLYMYL YFVIFIIFGA FFTLNLFIGV IIDNFNQQKK
     KFGGKDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPQNKIQ GVVFDFVSKQ AFDIFIMVLI
     CLNMVTMMIE TDDQSAEKEE ILYWVNLVFI VVFTGECILK IIALRHYYFT MGWNIFDFVV
     VILSVVGIML ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF
     NIGLLLFLVM FIYSIFGMSN FAYVKREAGI DDIFNFETFG NSIICLFQIT TSAGWDGLLS
     PILNSGPPDC DPTIENPGTD VKGDCGNPSV GIVFFCSYII ISFLIVVNMY IAIILENFNV
     ATEESAEPLC EDDFEMFYET WEKFDPDATQ FIDYCKLSDF VDTLQDPLKI PKPNRIKLIT
     MDLPMVAGDK IHCLDILFAL TKEVLGDSGE MDALKQTMEE KFMAANPSKV SYEPITSTLK
     RRHEEVSVTI IQRAYRRHLF MRSVKQASYM YRQNEECSPD EEAPEKEGLI ATKMKAFYGK
     GNETEEEMPA SAPRTGTSPS EDKDWDEKGN VRESIV
//
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