ID H3AP66_LATCH Unreviewed; 692 AA.
AC H3AP66;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Calcium/calmodulin dependent serine protein kinase {ECO:0000313|Ensembl:ENSLACP00000011437.1};
GN Name=CASK {ECO:0000313|Ensembl:ENSLACP00000011437.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000011437.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000011437.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; AFYH01165845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AP66; -.
DR STRING; 7897.ENSLACP00000011437; -.
DR Ensembl; ENSLACT00000011523.1; ENSLACP00000011437.1; ENSLACG00000010060.1.
DR eggNOG; KOG0033; Eukaryota.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000155600; -.
DR HOGENOM; CLU_001715_5_3_1; -.
DR InParanoid; H3AP66; -.
DR OMA; STKWASF; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010060; Expressed in pelvic fin and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12035; SH3_MPP1-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.650; L27 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF40; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..104
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 165..220
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 224..277
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 312..393
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 434..504
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 563..692
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 281..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 78777 MW; E4F2624A0317AB6A CRC64;
MCFSIGRVGT PHFMAPEVVK REPYGKPVDV WGCGVILFIL LSGCLPFYGT KERLFEGIIK
GKYKMNPRQW SHISESAKDL VRRMLMLDPA ERITVYEALN HPWLKERDRY AYKIHLPETV
EMLRKFNARR KLKGAVLAAV SSHKFNSFYG DPPEELPDFS EDPTSSGAVS QVLDSLEEIH
ALTDCSEKDL DFLHSVFQDQ HLHTLLDLYD KINTKSSPQI RNPPSDAVQR AKEVLEEISC
YPENIDAKEL KRILTQPHFM ALLQTHDVVA HEVYSDDALR VTPPPTSPYL NGDSPESANG
DMDMENVTRV RLVQFQKNTD EPMGITLKMN ELNHCIVARI MHGGMIHRQG TLHVGDEIRE
INGISVANQT VEQLQKMLRE MRGSITFKIV PSYRTQSSSC ERDSPSTSRQ SPANGHTSIN
NSILDLPSTT QPKGRQIYVR AQFDYDPSKD DLIPCKEAGI RFRVGDIIQI ISKDDHNWWQ
GKLENAKNGT AGLIPSPELQ EWRVACIAME KTKQEQQASC TWFGKKKKQY KDKYLAKHNA
VFDQLDLVTY EEVVKLPAFK RKTLVLLVTG AHGVGRRHIK NTLITKHPDR FAYPIPHTTR
PPKKDEENGK NYFFVTHDQM MQDISNNEYL EYGSHEDAMY GTKLETIRKI HEQGLIAILD
VEPQALKVLR TAEFAPFVVF IAAPTITPGM NE
//
