ID H3ARA2_LATCH Unreviewed; 602 AA.
AC H3ARA2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=SHC-transforming protein 1 {ECO:0000256|ARBA:ARBA00020297};
DE AltName: Full=Src homology 2 domain-containing-transforming protein C1 {ECO:0000256|ARBA:ARBA00031530};
GN Name=SHC1 {ECO:0000313|Ensembl:ENSLACP00000012173.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012173.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000012173.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AFYH01140242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01140250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3ARA2; -.
DR STRING; 7897.ENSLACP00000012173; -.
DR Ensembl; ENSLACT00000012265.1; ENSLACP00000012173.1; ENSLACG00000010713.1.
DR eggNOG; KOG3697; Eukaryota.
DR GeneTree; ENSGT00950000182870; -.
DR InParanoid; H3ARA2; -.
DR OMA; DKPRMEH; -.
DR TreeFam; TF315807; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010713; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF2; SHC-TRANSFORMING PROTEIN 1; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 165..348
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 507..598
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 346..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 65721 MW; CD07FBB5B79E200D CRC64;
MDMLQKSKYN HLRNESVTSF EEVAAGASLE ILTAQSLSTS VSSSSLTPML PINELSSESE
DSPTTLCSFF PKMANLKLSN PANLLNLKGF TAGMREVGSP AGEEVHTAAT TTVEPSAVAM
DMNKLSCGKK TRVEGGQLGG DEWTRHGSFV NKPTRGWLHP DDKVMGPGVA YLVRYMGCVE
VLQSMRALDF NTRTQVTREA ISVVCEAVPG AKGASRRRKP CSRSLTSILG KSNLRFAGMP
ITLTISTSSL NLMAADCKQI IANHHMQSIS FASGGDPDTA EYVAYVAKDP VNQRACHILE
CPEGLAQDVI STIGQAFELR FKQYLKNPPK LVTPHDRMAG FDGSAWDEEE EEQPDHQYYN
DFPGKEPPIG GVVDMRLREG ASPGQPRNLA PTQPPNHLGA TLPVGQMSSN QFDPQKQLPA
VQGIDCPSRS DLFDDPSYVN VQNMDKSRQP SGAATGATNG KAQRDLFDMK PFEDALRGPA
PLPASQVGLP PAQVVASMEE QLRWEIWYHG KISRKDAEKL LKSNGDFLVR ESTTTPGQYV
LTGLQNGQPK HLLLVDPEGV VRTKDHRFES VSHLISYHMD NHLPIISAGS EVCLQQPVER
RL
//
