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Database: UniProt
Entry: H3AT18_LATCH
LinkDB: H3AT18_LATCH
Original site: H3AT18_LATCH 
ID   H3AT18_LATCH            Unreviewed;       876 AA.
AC   H3AT18;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-DEC-2017, entry version 29.
DE   SubName: Full=N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 {ECO:0000313|Ensembl:ENSLACP00000012789};
GN   Name=LOC102363669 {ECO:0000313|Ensembl:ENSLACP00000012789};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000012789, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000012789}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000012789};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000012789}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000012789}.
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DR   EMBL; AFYH01094661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000012789; -.
DR   Ensembl; ENSLACT00000012883; ENSLACP00000012789; ENSLACG00000011266.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   GeneTree; ENSGT00760000119023; -.
DR   InParanoid; H3AT18; -.
DR   OMA; VSMDSWN; -.
DR   OrthoDB; EOG091G02CP; -.
DR   TreeFam; TF313193; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     16     36       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    509       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      599    849       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   876 AA;  101079 MW;  0E8A6038D67EE7BE CRC64;
     HKMNFATKFR RSLRRLVILL ATFCMVSIVI SAYYLYSGYN EEVELAATTP HVECNDLTVL
     PYRLQGVRTV AKPIDTSRAE PVILVFVESQ YSQLGQDIVA ILESSGFQYH TEIALSKGDL
     PSLTNKGRGK YMLVIYENIL KYVNMDSWNR SLLEKYCVEY GASIIGFYKA NENSLPSAKL
     KGFPLHLYTK LSLIDCFVNS HSPLLHITKA SEIERGPLPE EEWTIFQFNH STYQPVLLAK
     LSSSNNIPPA LSKDTLHATV VQDLGLHDGI QRVLFGNNLN FWLHKLIFVD AISFLSGKKL
     SLSLERYILV DIDDIFVGKE GTRMNANDVK ALLDTQKLLR TQVANFTFNL GFSGKFYHTG
     AEEEDDGDDL LLKYVDEFWW FPHMWNHMQP HLFHNESTLA DQMILNREFA LEHGIPTDMG
     YAVAPHHSGV YPVHVQLYEA WKKVWGIKVT STEEYPHLKP ARYRRGFIHN NIMVLPRQTC
     GLFTHTIFYK EYPGGPKELD KSIRGGELFL TVLLNPISIF MTHLSNYGND RLGLYTFVNL
     ARFVERWTNL KLRTLPPVQL AHKYFQLFPQ HKEPLWQSPC DDKRHKDIWS KEKTCYRLPK
     FLVIGPQKTG TSALFLFLIM HPSIISNFPS LKTFEEVQFF SGNSYHKGID WYMNFFPIPS
     NVSSSFLFEK SSTYFSSEEA PKRAAALLPK AKIITIFIDP SDRAYSWYQH QRAHEDPTAL
     KFSFYEVITA GHQAPAELRT LQKRCLVPGW YSTHIERWLA YFSATQLLII DGQQLRNDPA
     AVMDEVQKFL GVSPRYNYSE ALTFDHQKGF WCQLLEEGRT KCLGKTKGRK YPPMDSESRA
     FLSNYYREHN VELSKLLHRL GQALPSWLRQ ELQNIR
//
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