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Database: UniProt
Entry: H3ATZ9_LATCH
LinkDB: H3ATZ9_LATCH
Original site: H3ATZ9_LATCH 
ID   H3ATZ9_LATCH            Unreviewed;      3465 AA.
AC   H3ATZ9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000013120};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013120, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000013120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000013120};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000013120}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLACP00000013120}.
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DR   EMBL; AFYH01020855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01020864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000013120; -.
DR   Ensembl; ENSLACT00000013216; ENSLACP00000013120; ENSLACG00000011554.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H3ATZ9; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM   2776   2795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2999   3019       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3074   3093       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3266   3287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3342   3365       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     62       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     2519   2554       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   3465 AA;  395841 MW;  E799EB7D1F997F40 CRC64;
     NNNGLEIGCL VDTATGLLTF TANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI
     KNVMPLSAGL FKSERKNPVP QCPPRLHVQF LTPVLWSRVP NQFLKVDVSR VNERHGWLVQ
     CAEPLQFMSL HISEENRSLD ILELTEQEDL LKFHYHTLRL YSAVCALGNN RVAHALCSHV
     DESQLLYAIK NKYMPGLLRT GYYDLLIDIH LSTYATARLM MNNEFIVPMT EETKSITLFP
     DENKKHGLPG IGLSTSLRPR MRFSSPSFIC INGECFQYSP EFTLEVLKAK TIEMLTEAVQ
     EGSLHVRDPV GGSTEFLFVP LIKLFYTLLI MGVFHNGDLK HILQLIEPSV FSEDSGQEED
     EVAEKDASKA EVAAAVSDEE PVPKEGLLQM KLPEPVKLQM CHLLQYLCDC QVRHRIEAIV
     AFSDDFVAKL QENQRFRYNE VMQALNMSAA LTAKKTKEFR SPPQEQINML LNFKDEKQEC
     PCPDEIQDHL LDFHEDLMKH CGIELDEERA NEGDSDSTIR GRLLNLMEKV AHLKKKEMEK
     PMEKETKKPT TLQQLISETM VRWTQESVIE DSELVRAMFV LLHRQYDGTG GLVRALPKTY
     TINAVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIHGL GNIMNNKVFY QHPNLMRALG
     MHETVMEVMV NVLGGGELKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS
     VGLASPSMRG STPLDVAAAS VMDNNELALA LREPDLEKVV QYLAGCGLQS CPMLISKGYP
     DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA
     MQEAINIAED PAKDGPSPTS GSSRTLDLEE EEDDTIHMGN AIMTFYAALI DLLGRCAPEM
     HLIHAGKGEA IRIRAILRSL IPLEDLEGVI SIPFQMPTLA KDGTVVEPDM SAGFCPDHKA
     AMVLFLDRVY GIEDQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP
     LLTKCAPLFA GTEPHASLID SLLHTVYRLS KGCSLTKAQR DAIEECLLAI CGQLRPSMMQ
     HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW
     GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPEYMESNYV TMMVKQCSVD AEGNFNPQPV
     DTTNINVPEK LDYFINKYAE HSHEKWSMEK FANGWVYGEA SNEATKVHQL LKPYKMLSEK
     EKEVYRWPIK ETLKTMLAWE WTIDRAREGD AIYFHNRTRR ISQSSQTDTA HGYSPRPIDM
     SNVTLSRDLH AMAEMLAENY HNIWAKKKKL ELEAKGGGNH PLLVPYDTLT AKEKSRDREK
     AQDILKFFQI NGYAISRGLK DLELDTPSIE KRFAYSFLQQ LITYVDEAQE YILEFVILLD
     GGTRGKGERF PHEQEIKFFA KVVLPLIDQY FKNHRLYFLS TASRPLSSGG HASNKEKEMV
     TSLFCKLGVL VRHRISLFGT DASSIVNCLH ILGQTLDART VMKTGLESVK MALRAFFDNS
     AEDLEKTMEN LKQGQFTHTR TQPKGVTQII NYTTVALLPV LSSLFEHIGQ HQFGEDLILD
     DVQVSCYRIL CSLYGLGTSK SIYVERQRPA LGECLAAFAS AFPVPFLETQ LNKYSSHSIY
     NTKTTRDRTA LNLPARVEEA GPNIPSLETL MEEIMELAES GIRYTQMPHV MEVILPMLCS
     YMSHWWEHGP ENNPEKAETC CTALTSEHMN TLLGNILKII HNNLGIDEGA WMKRLAVFSQ
     PIISKAKPQL LKTHFLPLME KLKKKAAMVV ADEEHLRAEG RGDMSETELL ILDEFTILVR
     DLYAFYPLLI RFVDYNRAKW LKEPSPEAEE LFRMVADVFI FWAKSHNFKR EEQNFVVQNE
     INNMSFLITD TKSKMSKALT SKASVSDQER KKMKRKGDRY SLQTSLIVAA LKRLLPVGLN
     ICAPGDQELI SLAKNRFSMK DTEDEVRDTI RNNLHLQGKL EDPAIRWQMA LYKDLPNRTE
     DTSDPERTVE RVLDMANVLF HLEQVEHPQR SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL
     PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKRPGEE PVEEDEGTKR LDPLHQLILL
     FSRTALTEKC KLEEDFLYMA YADIMAKSCH DEEDDDGEEE VKSFEEKEME KQNLLYQQAR
     LHDRGAAEMV LQMISASKGE MGPMVAATLK LGIAILNGGN STVQQKMLDY LKDKKDVGFF
     QSLAGLMQSC SVLDLNAFER QNKAEGLGMV TEEGSVITHE RGEKVMQDDE FTCDLFRFLQ
     LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR
     NFSKAIKVAK QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ
     IELLKELMDL QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK
     DLTSSDAFKE YDPDGKGVIS KRDFHKAMES HKHYTQSETE FLLSCAETDE NEMLDYEEFV
     ERFHEPAKDI GFNVAVLLTN LSEHMPHDTR LQTFLELAES VLNYFQPYLG RIEIMGSAKR
     IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA
     QISESDTSER STSKDDNEKD RFEEQDPKMG FFTITTIRSA LVALRYNVMI LMKLLSMKSL
     KKQVKKMKKM TMKDMVMALV SSYWCLLVGL LHFTFSVFRG FFRIMYSTFL GGSLVEGAKK
     IKVAELLANM PDPTQDEVRG EGDESEQKNT NTSLLSEDLT DLTAASDEGD LLSDIFGLDL
     KREGGQYKLI PHNPNAGLSD LMSAPSVPTL FPEFRRRFQG EKIKEDERED KEESKSETEK
     AEGEDGEKQE NAKEEKSKQK YRQHHTQKSG EPEVQESAFW KKIIAYQQKL LNYFARNFYN
     MRMLALFVAF AINFILLFYK VSTSAIIEEK EIPFGGRGDE NHRWNSMGVG SHRIITVHYV
     LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ
     PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS
     DAQEKKKSKA NGVKRLNSID VKYQIWKLGV VFTDNSFLYL AWYMTMSVLG HYNNFFFAAH
     LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDGDTP
     DMKCDDMLTC YMFHMYVGVR AGGGIGDEIE DPAGDEYEIY RIIFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGNDYFDTVP HGFETHTLQE HNLANYLFFL
     MYLINKDETE HTGQESYVWK MYQERCWEFF PAGDCFRKQY EDQLN
//
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