ID H3AVP4_LATCH Unreviewed; 1176 AA.
AC H3AVP4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=L1 cell adhesion molecule {ECO:0000313|Ensembl:ENSLACP00000013715.1};
GN Name=L1CAM {ECO:0000313|Ensembl:ENSLACP00000013715.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000013715.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000013715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AFYH01101173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01101182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AVP4; -.
DR STRING; 7897.ENSLACP00000013715; -.
DR Ensembl; ENSLACT00000013812.1; ENSLACP00000013715.1; ENSLACG00000012070.1.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157506; -.
DR HOGENOM; CLU_005756_1_1_1; -.
DR InParanoid; H3AVP4; -.
DR OMA; GARTIIQ; -.
DR TreeFam; TF351098; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000012070; Expressed in pectoral fin and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF44; L1 CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1040..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..62
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 173..261
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 358..445
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 625..719
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..826
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 830..926
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 929..1028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1095..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 131708 MW; 08CB7E25F347D8A0 CRC64;
RFRWTKNGKI IDLKQDPRIV TKANSGTFSI ANNNGIGLKS YQGKYRCYAA NDLGTAISTE
INLIVESAPK WPKDKVTLFE VEEGDSVVLP CNPPVTEAPS RIYWMGEMLE HIAQDSRVSQ
GLNGDLYFTN VLKNDSRKDL MCHFQFLGAR TISQKEPIEL KVLPSNSLTL RKPRLLNPTG
ESSRHLVLRG TTLQLECFAE GLPTPKIHWK RLDDKLPKDR FSEESFSKIL RIENVTESDD
GEYQCIVENT EGTVKHSFSV TVEGIQYVRH TGSSGGMYPA DENGIFVQCP GPKDIFLIFF
EGGEAEETDP DPALNVKDGT LYLSNAQMKN TAVFQCEATN KHGSILANAY IFVLKLPPQI
LNKNNMHYVV VEKQTAFLEC RAFGLPFPEL TWNKEDIETV TADSRYSILH NGTLKISDVQ
KDDIGLFFCT TSNELDNTTI TATLDVKDAT KVEIYPVDQR VRKLDKATFE CDFYFDPSIG
ETDVKWKKDG IQIEESDDSG NLSPTPMLFL SHFLSLSHSH ALSLSLPPLV LSPFPSPSHS
LSPSPLSFSL PPPLSFSPFL ILSPIPMLFL SSSPSHSLSP TPMLSLFLPL SFSLSHSHAL
SLFLPPLVLS PFPSHSLSPI TMLSLPPPLV LSPSPKNSNK GICTKPLRGL DWNGPNFLYR
VTWRQKGKEN LWHTATTENS WITVNNTPPF VPYEITVQSI NEMGPGPVPE IFIGHSGEDE
PQAYPVNVAV EFINSTSIRV VWSAVPKEDI RGHLGGYKVY YWRSHSLLER GKRHTDSHVV
MVRGEKTHVL LSNLEPFSKY ILQVTVFNGK EEGPRSPRFE FKTPEGVPSS PMSLHLENLS
EMSVKLTWDP PLRHNGILTE YLLQYQQFNE TDSSSLIDVR IDKPKQSSWI LVNLDPKGTY
RFYLRARTSI GYGQPIIKEE SWVKSPKIPP ALLNISHSSG KTHINISWIT REGHRNVEFQ
IHYRNKNKKK EKKCNQLNPP HKVNSTQAFY KLQDLNPGTE YQIKFVARNR TTDVSFWETE
VETEGPGPLK GIHDEFATQG WFIGLASAIA LLLLILLIIC FIKRNKGGKY SVKDKEEAHV
DSEARPMKDE TFGEYRSLES DNEEKPFTSS QPSLNGDIKP LGSDDSLADY GGSVDVQFNE
DGSFIGQYSG KKEKDVPGGN DSSGATSPVN AVITLE
//
