ID H3AWN3_LATCH Unreviewed; 1691 AA.
AC H3AWN3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Complement C5 {ECO:0000313|Ensembl:ENSLACP00000014054.2};
GN Name=C5 {ECO:0000313|Ensembl:ENSLACP00000014054.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014054.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014054.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AFYH01007848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014346298.1; XM_014490812.1.
DR SMR; H3AWN3; -.
DR STRING; 7897.ENSLACP00000014054; -.
DR Ensembl; ENSLACT00000014153.2; ENSLACP00000014054.2; ENSLACG00000012370.2.
DR GeneID; 102364499; -.
DR KEGG; lcm:102364499; -.
DR CTD; 727; -.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000155670; -.
DR HOGENOM; CLU_001634_4_2_1; -.
DR InParanoid; H3AWN3; -.
DR OMA; YKRIIAC; -.
DR OrthoDB; 4033541at2759; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048843; C5_CUB.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF83; COMPLEMENT C5; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21309; C5_CUB; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1691
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580687"
FT DOMAIN 703..738
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1545..1690
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1691 AA; 190052 MW; B2E73E924633967C CRC64;
MMKFFYIFFV LALCERSICQ EQTYLLTAPR VFRVGATETV VVQTFGYDDG FSVNIAIKSF
PDKKTTFASE SLSLSNANNF QGSVTLTIQP KDLPRKDSSK VYVYLEASSP GFTKEEKVLV
SYQNGFLFIQ LDKPIYTPDQ SVKVRVYSLN EDLKPARKPI TLTFVDPEGV KVDIIEGDDF
TGVVSVPHFK IPSNPRYGIW KTEAAYKSDY TTSAIAEFEV KEYAMPSFSL SIEPERNFIS
YDRFENFNIA IKASYFYGKK VSRADVYVRF GIIDEQQEKT MLSGVIVAQL TEGVAEIFLD
SKTEFARLGR ESLEDLDGSY LYITVSVQEY SGGHTEEAEL AEVKYVMSPY SINLVATPSY
VKPGLPFHIQ VQVKDTLGQP VGNIPVTLTA VAFDENHEEI SLVDENSEQG KRDTLRANGV
ALFVVNIPMT VNTLQFKVKT ADTTLTEESQ ISREYEARVY SSLTNSYLYI HITGSPTGLR
VGNYFNVNLL ASSPYKSKIK QFGYQVMSKG KLVIFGTIDF SEGVVVHNLN IEVTSEMVPS
ARLIVYYVVT GEGSAELVVD SVWINVEEKC TSKKQVVLSK DAEVYKPGKD MFLSIEAEPS
SFVALSSVDS AIYGVRTKAK KSIERMLQHI EKSDLGCGAG GGKNNADVFR LAGLTFMTNA
NAKALEEHDE PCTVIMRPKR SVNFEKQVEQ ELSRFKNPTY KKCCLDGIKA YPITETCDQR
ARRIRKGEQC FKAFRYCCQF ANKLRFQSHT HTTLGRMNIV ASLEVEETQV RSYFPESWLW
EVHEVTARSG SKRLAVTLPD SLTTWQIQGI GISDNGICVA DPLKVQVFKE VFLKMQMPYS
VIRGEQIELR GSIYNYKEVP NTALVSMTVG DGICLFKGSA TGSKGTQSPP IKMVVRGSSV
SSVSYVILPL ELGLHTINFT LKSQYGNEIV MHTLRVVPEG IKKEQNVGVT LDPQGIYGFI
KRRHEFRYMT PKNVVPKSDI NRTVSVKGEI MGEIIATVLS AEGLNLLNNL PRGSGEAELM
SIVPVYYVFY YLEKSDNWKI LGSKTLTIRM NMRRKMIEGV TSILSFKVKG GHAYSMWKDG
VPSTWLTAFV VRIFGELNEY VPLDEMSVCN SVMWLIEDCQ KSNGLFKETS NYQAVKLQGT
IPKESEEREI YLTAFTVIGI QKAFHMCPTR GIQDAIFKAI DILSNKWKNV QSTYTLAITA
YALAVQNRRT LAARFAFASL KKEALVKGNP PVYRFWKETS SQVDTSTPSV VTARIVETTA
YALLVTILNG DMNYAKPIIK WLSEQQRYGG GFYSTQDTII ALQSLTEYAV LLKRSELDMI
IKVSNKKHGE FLHFEMTEEK SLVRAEEVPK DDDLVISTGS GTGISTVHIK TVYHAVSTSE
ENCDFSLRIQ GTPNIDPLSA GTRKRRESEP LQRIEACAKY LPRKNEEFTE SSHAVMDIGL
VTGLAAEEED LDTLANGVDN LISDYKIADG HVILQLDQIP SDDYICVAFR VREMFNVGML
SPAVFTVYEY HTPDRRCSIF YNPYGNEKLV KLCQGNECKC MEVECSQMQK EINLTVSAND
RIEAACKEDI VYAYKVNILS AKEDGNFVKY SASILDIYKK GADRVKQTMV VTFIKKKTCT
DVLKIGKHYL IMGTEGIETK NYMTLEYDYP LDSKVWIELW PSEQDCDVDT CTDFIKTLEE
FSENVLFFGC S
//