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Database: UniProt
Entry: H3AX67_LATCH
LinkDB: H3AX67_LATCH
Original site: H3AX67_LATCH 
ID   H3AX67_LATCH            Unreviewed;      1041 AA.
AC   H3AX67;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014238, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000014238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000014238};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000014238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AFYH01123730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01123731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01123732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01123733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01123734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLACT00000014338; ENSLACP00000014238; ENSLACG00000012536.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     20     39       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     82    104       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    142    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    212    239       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    346    364       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    384    407       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    413    431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    460    486       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    605       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    667    685       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    697    715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    812       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    835    855       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    867    893       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       14    243       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      344    615       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      665    903       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      909    963       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1041 AA;  118341 MW;  780EA0CC300DB3AB CRC64;
     FLKVQEKLVK VVSHSLFEGI ITVCIIINTL MLSIDYYNAP YSEDLEEGNK VLTVIFIAEA
     VLKILALNPV PYIKNPWNAF DFIIVCLSIL DLGLSAIDIA SFDLSIMRSL RMLRIFKLAK
     NWRTLNVLIT IIFGSLKEMG NLTLIVVIVI YIFAVIGMQL VGQDYKNADA FPDKEVPRWN
     FTNFYASFLM VFRILCGEWL EPLYDCLRCS KIYFCIPLFL LTFITGNFLV LNLFLALLLN
     FFSGDKLTAT KKYTSFFLNT TGPHWPCVSY FVSDVNVESV KSSNAVDPTS QTVFSAKKNS
     NEMQPCFPVC CSKCCCCGGG SSVDTPVGEI CFSLRMQTFR LVNNRVFDAI VLFVILASTA
     TLTLDDKYTQ SNAKIQLALK YLDYFYTAFF NLEMILKIVG LGLTFYFTNV WTLLDFFLVV
     VGWLGIIGSS VKSLKSLRSL RTLRALRPLR AISRWEGMRL VVNALVASIP SISNVMLVCL
     VFWLIFGIVG VQIYGGKFFQ CLDENGNRLP ITVVNNRSEC ESNANKGYQW VNAEINFDNI
     LSTYIILLQV ATFEGWVEIM AIAADTRGVD IQPETGANIY SLLYFVAFIV VGSFFTLNLF
     IGVIIDNFNT VHKRSRQEGA LVILLTEDQK RLYGILKRLT KAKPKKTIPP PENKFLFLFY
     KLVNHKVFEP FNLCLIVLNV LVMASDHYNL SEDFSVALYW FNLIFTALFT VEAILKLLGL
     RLYYFTQAWN IFDILVVVFS IVGNILDSLS ASLGFSPTIL RVFRVVRLGR LLRLVRSLKG
     IRKLLYTLIV SIPALFNIGL LLTLVMFIYS ILGMNLFRNL PRTEIINDFV NFETFANSML
     LLFRLTTAAG WNEILQELLV SDIQPSIVCV IYMSTYIIIT FLVIVNMYVA IILENFNEAQ
     EQELAGITDD DIDMYYEVWS TYDPYATQFI AYEQLSDFLD ELKPPLKIPK PNAVKIAALN
     LPLTNGHKLH CLDILKALSC VMIGNVTETD PLKKLHNQIN EKSQKTFPIR LTMQTVSTTL
     MIRKEIKAAM TIQKAFRKWQ Q
//
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